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   Articles with "intracellular loop" as a keyword



The Intracellular Loop of the Na+/Ca2+ Exchanger Contains an "Awareness Ribbon"-Shaped Two-Helix Bundle Domain.

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recommendations! Published in 2018 at "Biochemistry"

DOI: 10.1021/acs.biochem.8b00300

Abstract: The Na+/Ca2+ exchanger (NCX) is a ubiquitous single-chain membrane protein that plays a major role in regulating the intracellular Ca2+ homeostasis by the counter transport of Na+ and Ca2+ across the cell membrane. Other than… read more here.

Keywords: ca2 exchanger; ca2; two helix; domain ... See more keywords

Coupling and Activation of the β1 Adrenergic Receptor - The Role of the Third Intracellular Loop

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recommendations! Published in 2024 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.4c11250

Abstract: G protein-coupled receptors (GPCRs) belong to the most diverse group of membrane receptors with a conserved structure of seven transmembrane (TM) α-helices connected by intracellular and extracellular loops. Intracellular loop 3 (ICL3) connects TM5 and… read more here.

Keywords: receptor; intracellular loop; activation; adrenergic receptor ... See more keywords

Mechanism of human α3β GlyR regulation by intracellular M3/M4 loop phosphorylation and 2,6-di-tert-butylphenol interaction

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recommendations! Published in 2025 at "Nature Communications"

DOI: 10.1038/s41467-025-60516-8

Abstract: α3β glycine receptor (GlyR) is a subtype of GlyRs that belongs to the Cys-loop receptor superfamily. It is highly expressed in the spinal dorsal horn where sensory information is integrated. Under inflammatory conditions, the large… read more here.

Keywords: glyr; intracellular loop; tert butylphenol; phosphorylation ... See more keywords

The third intracellular loop of Drosophila Lilipod is required for protein function in vivo and can mediate protein-protein interactions in vitro

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recommendations! Published in 2025 at "PLOS One"

DOI: 10.1371/journal.pone.0325326

Abstract: The evolutionarily conserved Lipocalin-Interacting Membrane Receptor (LIMR) family (InterPro: IPR006876) consists of transmembrane (TM) proteins characterized by 9 TM domains (TMDs). Their reported biological functions are diverse and remain poorly understood. In previous work, we… read more here.

Keywords: protein; lili; intracellular loop; function vivo ... See more keywords