Quantitative imaging of intracellular nanoparticle exposure enables prediction of nanotherapeutic efficacy
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-22678-z
Abstract: Nanoparticle internalisation is crucial for the precise delivery of drug/genes to its intracellular targets. Conventional quantification strategies can provide the overall profiling of nanoparticle biodistribution, but fail to unambiguously differentiate the intracellularly bioavailable particles from… read more here.
Keywords: nanoparticle; quantitative imaging; nanoparticle exposure; intracellular nanoparticle ... See more keywords
Intracellular nanoparticle delivery by oncogenic KRAS-mediated macropinocytosis
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Nanomedicine"
DOI: 10.2147/ijn.s212861
Abstract: Background The RAS family of oncogenes (KRAS, HRAS, NRAS) are the most frequent mutations in cancers and regulate key signaling pathways that drive tumor progression. As a result, drug delivery targeting RAS-driven tumors has been… read more here.
Keywords: intracellular nanoparticle; microscopy; cancer cells; macropinocytosis ... See more keywords