Intracellular Pharmacokinetics of Pyrimidine Analogues used in Oncology and the Correlation with Drug Action
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DOI: 10.1007/s40262-020-00934-7
Abstract: Pyrimidine analogues can be considered as prodrugs, like their natural counterparts, they have to be activated within the cell. The intracellular activation involves several metabolic steps including sequential phosphorylation to its monophosphate, diphosphate and triphosphate.… read more here.
Keywords: pyrimidine analogues; nucleotide concentrations; intracellular nucleotide; oncology ... See more keywords