Intracellular Pharmacokinetics of Pyrimidine Analogues used in Oncology and the Correlation with Drug Action
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DOI: 10.1007/s40262-020-00934-7
Abstract: Pyrimidine analogues can be considered as prodrugs, like their natural counterparts, they have to be activated within the cell. The intracellular activation involves several metabolic steps including sequential phosphorylation to its monophosphate, diphosphate and triphosphate.… read more here.
Keywords: pyrimidine analogues; nucleotide concentrations; intracellular nucleotide; oncology ... See more keywords
Ultrasound enhances ZD2767P‒carboxypeptidase G2 against chemoresistant ovarian cancer cells by altering the intracellular pharmacokinetics of ZD2767D.
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DOI: 10.1021/acs.molpharmaceut.0c00008
Abstract: Prodrug‒carboxypeptidase G2 (e.g., ZD2767P+CPG2) can realize a targeted treatment where the specific advantage is a lack of CPG2 analogs in humans, but it is limited by low efficacy. Here ultrasound was employed to enhance ZD2767P+CPG2… read more here.
Keywords: cpg2; ovarian cancer; cancer cells; zd2767p cpg2 ... See more keywords