Interaction of Periplasmic Fab Production and Intracellular Redox Balance in Escherichia coli Affects Product Yield
Sign Up to like & getrecommendations! Published in 2022 at "ACS Synthetic Biology"
DOI: 10.1021/acssynbio.1c00502
Abstract: Antibody fragments such as Fab’s require the formation of disulfide bonds to achieve a proper folding state. During their recombinant, periplasmic expression in Escherichia coli, oxidative folding is mediated by the DsbA/DsbB system in concert… read more here.
Keywords: fab; escherichia coli; intracellular redox; cell ... See more keywords
Tip110 Expression Facilitates the Release of HEXIM1 and pTEFb from the 7SK Ribonucleoprotein Complex Involving Regulation of the Intracellular Redox Level
Sign Up to like & getrecommendations! Published in 2021 at "Aging and Disease"
DOI: 10.14336/ad.2021.0528
Abstract: HIV-1 Tat-interacting protein of 110 kDa (Tip110; p110nrb/SART3) has been identified to be important for HIV gene transcription and several host gene expression. In this study, we showed that Tip110 was present in the 7SK… read more here.
Keywords: expression; 7sk snrnp; tip110 expression; intracellular redox ... See more keywords
The impact of chronic stress on intracellular redox balance: A systems level analysis
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DOI: 10.14814/phy2.15640
Abstract: Chronic psychosocial stress is implicated in the onset and progression of noncommunicable diseases, and mechanisms underlying this relationship include alterations to the intracellular redox state. However, such changes are often investigated in isolation, with few… read more here.
Keywords: stress; stressed rats; redox; chronic stress ... See more keywords
Targeting of the intracellular redox balance by metal complexes towards anticancer therapy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2022.967337
Abstract: The development of cancers is often linked to the alteration of essential redox processes, and therefore, oxidoreductases involved in such mechanisms can be considered as attractive molecular targets for the development of new therapeutic strategies.… read more here.
Keywords: metal complexes; redox; redox balance; targeting intracellular ... See more keywords
The Lack of the TetR-Like Repressor Gene BCG_2177c (Rv2160A) May Help Mycobacteria Overcome Intracellular Redox Stress and Survive Longer Inside Macrophages When Surrounded by a Lipid Environment
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DOI: 10.3389/fcimb.2022.907890
Abstract: Mycobacteria, like other microorganisms, survive under different environmental variations by expressing an efficient adaptive response, oriented by regulatory elements, such as transcriptional repressors of the TetR family. These repressors in mycobacteria also appear to be… read more here.
Keywords: gene; bcg 2177c; tetr like; longer inside ... See more keywords
A Diet Containing Rutin Ameliorates Brain Intracellular Redox Homeostasis in a Mouse Model of Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24054863
Abstract: Quercetin has been studied extensively for its anti-Alzheimer’s disease (AD) and anti-aging effects. Our previous studies have found that quercetin and in its glycoside form, rutin, can modulate the proteasome function in neuroblastoma cells. We… read more here.
Keywords: quercetin rutin; tgapp mice; rutin; redox homeostasis ... See more keywords