Fundamental insights into the interaction between telomerase/TERT and intracellular signaling pathways.
Sign Up to like & getrecommendations! Published in 2020 at "Biochimie"
DOI: 10.1016/j.biochi.2020.11.015
Abstract: Telomerase activity is critical for cancer cells to provide unrestricted proliferation and cellular immortality through maintaining telomeres. Telomerase enzymatic activity is regulatable at the level of DNA, mRNA, post translational modifications, cellular transport and enzyme… read more here.
Keywords: signaling pathways; telomerase; tert; intracellular signaling ... See more keywords
The oxidation state of cysteine thiols on the ectodomain of TLR2 and TLR4 influences intracellular signaling.
Sign Up to like & getrecommendations! Published in 2019 at "Immunobiology"
DOI: 10.1016/j.imbio.2019.12.004
Abstract: Signal transduction by the Toll-like receptors (TLRs) is a key component of innate immunity against many pathogens and also underlies a large burden of human diseases. Therefore, the mechanisms and regulation of signaling from the… read more here.
Keywords: oxidation; cysteine; intracellular signaling; tlr2 tlr4 ... See more keywords
Testing biologics and intracellular signaling inhibitors on pediatric atopic dermatitis: a stairway to modern therapeutic approaches
Sign Up to like & getrecommendations! Published in 2018 at "Expert Opinion on Investigational Drugs"
DOI: 10.1080/13543784.2018.1516748
Abstract: ABSTRACT Introduction: Atopic dermatitis (AD) is the most common cutaneous inflammatory disease in adults and children. In the last few years, the pathogenesis of AD has been profoundly revised, and this has led to the… read more here.
Keywords: biologics intracellular; intracellular signaling; atopic dermatitis; testing biologics ... See more keywords
Intracellular signaling in CRISPR-Cas defense
Sign Up to like & getrecommendations! Published in 2017 at "Science"
DOI: 10.1126/science.aao2210
Abstract: New molecular communication in type III CRISPR-Cas systems has been identified The CRISPR-Cas (clustered regularly interspaced short palindromic repeats-CRISPR-associated protein) system is known to protect bacteria against foreign invading DNA, usually from phages (viruses that… read more here.
Keywords: defense; crispr cas; intracellular signaling; cas ... See more keywords
The Anti-COVID-19 Drug Remdesivir Promotes Oncogenic Herpesvirus Reactivation through Regulation of Intracellular Signaling Pathways
Sign Up to like & getrecommendations! Published in 2022 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.02395-21
Abstract: Recently, Remdesivir and Molnupiravir were approved for treating COVID-19 caused by SARS-CoV-2 infection. However, little is known about the impact of these drugs on other viruses preexisted in COVID-19 patients. ABSTRACT Recently, remdesivir and molnupiravir… read more here.
Keywords: signaling pathways; reactivation; herpesvirus; intracellular signaling ... See more keywords
Kaposi's Sarcoma-Associated Herpesvirus Nonstructural Membrane Protein pK15 Recruits the Class II Phosphatidylinositol 3-Kinase PI3K-C2α To Activate Productive Viral Replication
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Virology"
DOI: 10.1128/jvi.00544-18
Abstract: The nonstructural membrane protein encoded by open reading frame K15 of Kaposi's sarcoma-associated herpesvirus (KSHV) (HHV8) activates several intracellular signaling pathways that contribute to the angiogenic properties of KSHV in endothelial cells and to its… read more here.
Keywords: protein; pi3k; kshv; intracellular signaling ... See more keywords
Tetraspanin CD63 Bridges Autophagic and Endosomal Processes To Regulate Exosomal Secretion and Intracellular Signaling of Epstein-Barr Virus LMP1
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Virology"
DOI: 10.1128/jvi.01969-17
Abstract: ABSTRACT The tetraspanin protein CD63 has been recently described as a key factor in extracellular vesicle (EV) production and endosomal cargo sorting. In the context of Epstein-Barr virus (EBV) infection, CD63 is required for the… read more here.
Keywords: protein; epstein barr; secretion; lmp1 ... See more keywords
Abstract 5744: Decreasing toxicity of immunocytokines by transient and selective inhibition of their intracellular signaling activation
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5744
Abstract: The use of cytokine-based therapeutics has traditionally been limited by systemic toxicity, but it is now becoming evident that it may be possible to circumvent this problem in a number of ways. Tumor-targeting antibody-cytokine fusion… read more here.
Keywords: immunocytokines transient; inhibition; intracellular signaling; inhibition intracellular ... See more keywords
Evidence that dopamine is involved in neuroendocrine regulation, gill intracellular signaling pathways and ion regulation in Litopenaeus vannamei
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Experimental Biology"
DOI: 10.1242/jeb.204073
Abstract: ABSTRACT The transport of ions and ammonia in gills may be regulated by neuroendocrine factors. In order to explore the mechanism of dopamine (DA) regulation, we investigated hemolymph neuroendocrine hormones, gill intracellular signaling pathways, ion… read more here.
Keywords: protein; signaling pathways; intracellular signaling; ion ... See more keywords
Toward high-throughput engineering techniques for improving CAR intracellular signaling domains
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2023.1101122
Abstract: Chimeric antigen receptors (CAR) are generated by linking extracellular antigen recognition domains with one or more intracellular signaling domains derived from the T-cell receptor complex or various co-stimulatory receptors. The choice and relative positioning of… read more here.
Keywords: intracellular signaling; chimeric antigen; high throughput; antigen receptors ... See more keywords
Identification of Intercellular Signaling Changes Across Conditions and Their Influence on Intracellular Signaling Response From Multiple Single-Cell Datasets
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2021.751158
Abstract: Identification of intercellular signaling changes across multiple single-cell RNA-sequencing (scRNA-seq) datasets as well as how intercellular communications affect intracellular transcription factors (TFs) to regulate target genes is crucial in understanding how distinct cell states respond… read more here.
Keywords: changes across; identification intercellular; signaling changes; cell ... See more keywords