Time- and Space-Resolved Flow-Cytometry of Cell Organelles to Quantify Nanoparticle Uptake and Intracellular Trafficking by Cells.
Sign Up to like & getrecommendations! Published in 2021 at "Small"
DOI: 10.1002/smll.202100887
Abstract: The design of targeted nanomedicines requires intracellular space- and time-resolved data of nanoparticle distribution following uptake. Current methods to study intracellular trafficking, such as dynamic colocalization by fluorescence microscopy in live cells, are usually low… read more here.
Keywords: space resolved; time; intracellular trafficking; flow cytometry ... See more keywords
Analysis of Actin-Based Intracellular Trafficking in Pollen Tubes.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7262-3_11
Abstract: Underlying rapid and directional pollen tube growth is the active intracellular trafficking system that carries materials necessary for cell wall synthesis and membrane expansion to the expanding point of the pollen tube. The actin cytoskeleton… read more here.
Keywords: intracellular trafficking; actin based; analysis actin; pollen tubes ... See more keywords
Monitoring of the Cytoskeleton-Dependent Intracellular Trafficking of Fluorescent Iron Oxide Nanoparticles by Nanoparticle Pulse-Chase Experiments in C6 Glioma Cells
Sign Up to like & getrecommendations! Published in 2018 at "Neurochemical Research"
DOI: 10.1007/s11064-018-2627-3
Abstract: Iron oxide nanoparticles (IONPs) are used for various biomedical and therapeutic approaches. To investigate the uptake and the intracellular trafficking of IONPs in neural cells we have performed nanoparticle pulse-chase experiments to visualize the internalization… read more here.
Keywords: nanoparticle pulse; fluorescent; pulse chase; iron ... See more keywords
Elucidation of cellular uptake and intracellular trafficking of heparosan polysaccharide-based micelles in various cancer cells.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2019.02.133
Abstract: Heparosan polysaccharide, known as a heparin precursor, can be used in drug delivery systems due to its good biocompatibility and anti-cancer effect. But few studies on the cellular uptake mechanism of heparosan polysaccharide-based nanocarrier have… read more here.
Keywords: heparosan polysaccharide; intracellular trafficking; cancer cells; cancer ... See more keywords
Exploring Endocytosis and Intracellular Trafficking of the Human Serotonin1A Receptor.
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DOI: 10.1021/acs.biochem.9b00033
Abstract: G protein-coupled receptors (GPCRs) represent the largest class of receptors involved in signal transduction across cell membranes and are major drug targets in all clinical areas. Endocytosis of GPCRs offers a regulatory mechanism for sustaining… read more here.
Keywords: serotonin1a receptor; human serotonin1a; endocytosis; receptor ... See more keywords
Cellular Uptake and Intracellular Trafficking of Poly( N-(2-Hydroxypropyl) Methacrylamide).
Sign Up to like & getrecommendations! Published in 2019 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.8b01372
Abstract: Cellular uptake and intracellular trafficking of polymer conjugates or polymer nanoparticles is typically monitored using fluorescence-based techniques such as confocal microscopy. While these methods have provided a wealth of insight into the internalization and trafficking… read more here.
Keywords: intracellular trafficking; microscopy; uptake intracellular; polymer ... See more keywords
Intracellular trafficking of Notch orchestrates temporal dynamics of Notch activity in the fly brain
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-22442-3
Abstract: While Delta non-autonomously activates Notch in neighboring cells, it autonomously inactivates Notch through cis-inhibition, the molecular mechanism and biological roles of which remain elusive. The wave of differentiation in the Drosophila brain, the ‘proneural wave’,… read more here.
Keywords: notch orchestrates; trafficking notch; notch; notch activity ... See more keywords
Effects of organic matter on uptake and intracellular trafficking of nanoparticles in Tetrahymena thermophila
Sign Up to like & getrecommendations! Published in 2019 at "Environmental Science: Nano"
DOI: 10.1039/c9en00303g
Abstract: Proteins could highly affect the uptake and intracellular trafficking of nanoparticles, which depends on the interaction between nanoparticles and proteins. read more here.
Keywords: organic matter; uptake intracellular; intracellular trafficking; effects organic ... See more keywords
Role of adaptin protein complexes in intracellular trafficking and their impact on diseases.
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DOI: 10.1080/21655979.2021.1982846
Abstract: Adaptin proteins (APs) play a crucial role in intracellular cell trafficking. The 'classical' role of APs is carried out by AP1‒3, which bind to clathrin, cargo, and accessory proteins. Accordingly, AP1-3 are crucial for both… read more here.
Keywords: adaptin protein; role adaptin; role; protein complexes ... See more keywords
M206. EFFECTS OF RISPERIDONE ON THE MRNA EXPRESSION OF PROTEINS INVOLVED IN INTRACELLULAR TRAFFICKING IN THE MICE EXPOSED TO SOCIAL DEFEAT STRESS
Sign Up to like & getrecommendations! Published in 2020 at "Schizophrenia Bulletin"
DOI: 10.1093/schbul/sbaa030.518
Abstract: Abstract Background Impaired intracellular trafficking has been proposed as a new key pathophysiology for neuropsychiatric disorders. The present study investigated the effects of risperidone on the mRNA levels of various proteins involved in intracellular trafficking,… read more here.
Keywords: social defeat; defeat stress; expression; mrna expression ... See more keywords
Abstract 5875: Rab37 mediates intracellular trafficking and membrane presentation of PD-1 in T cells to foster an immunosuppressive microenvironment in lung cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5875
Abstract: Programmed cell death protein 1 (PD-1) expressed on the surface of CD8+ T cells is known as an immune checkpoint protein. High expression of PD-1 leads to T-cell dysfunction in the tumor microenvironment (TME). Our… read more here.
Keywords: rab37; membrane presentation; intracellular trafficking; membrane ... See more keywords