MYO9A deficiency in motor neurons is associated with reduced neuromuscular agrin secretion
Sign Up to like & getrecommendations! Published in 2018 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddy054
Abstract: Abstract Congenital myasthenic syndromes (CMS) are a group of rare, inherited disorders characterized by compromised function of the neuromuscular junction, manifesting with fatigable muscle weakness. Mutations in MYO9A were previously identified as causative for CMS… read more here.
Keywords: secretion; agrin; intracellular transport; motor ... See more keywords
Models of Intracellular Transport: Pros and Cons
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2019.00146
Abstract: Intracellular transport is one of the most confusing issues in the field of cell biology. Many different models and their combinations have been proposed to explain the experimental data on intracellular transport. Here, we analyse… read more here.
Keywords: models intracellular; transport; transport pros; model ... See more keywords
Phosphoregulation of Kinesins Involved in Long-Range Intracellular Transport
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.873164
Abstract: Kinesins, the microtubule-dependent mechanochemical enzymes, power a variety of intracellular movements. Regulation of Kinesin activity and Kinesin-Cargo interactions determine the direction, timing and flux of various intracellular transports. This review examines how phosphorylation of Kinesin… read more here.
Keywords: long range; intracellular transport; range; phosphoregulation kinesins ... See more keywords
Held Up in Traffic—Defects in the Trafficking Machinery in Charcot-Marie-Tooth Disease
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2021.695294
Abstract: Charcot-Marie-Tooth disease (CMT), also known as motor and sensory neuropathy, describes a clinically and genetically heterogenous group of disorders affecting the peripheral nervous system. CMT typically arises in early adulthood and is manifested by progressive… read more here.
Keywords: cmt; defects trafficking; charcot marie; intracellular transport ... See more keywords
COVID-19 Biogenesis and Intracellular Transport
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24054523
Abstract: SARS-CoV-2 is responsible for the COVID-19 pandemic. The structure of SARS-CoV-2 and most of its proteins of have been deciphered. SARS-CoV-2 enters cells through the endocytic pathway and perforates the endosomes’ membranes, and its (+)… read more here.
Keywords: covid biogenesis; intracellular transport; sars cov; biogenesis intracellular ... See more keywords
Intracellular Membrane Transport in Vascular Endothelial Cells
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24065791
Abstract: The main component of blood and lymphatic vessels is the endothelium covering their luminal surface. It plays a significant role in many cardiovascular diseases. Tremendous progress has been made in deciphering of molecular mechanisms involved… read more here.
Keywords: membrane transport; intracellular membrane; transport vascular; endothelial cells ... See more keywords
Understanding the Golgi Apparatus and Intracellular Transport Pathways
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24087549
Abstract: Today, the future paradigm of intracellular transport could be based on four competing models, namely the vesicular model, the cisterna maturation-progression model, the diffusion model, and the kiss-and-run model [...]. read more here.
Keywords: intracellular transport; apparatus intracellular; transport pathways; transport ... See more keywords
The Regulated Secretion and Models of Intracellular Transport: The Goblet Cell as an Example
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24119560
Abstract: Transport models are extremely important to map thousands of proteins and their interactions inside a cell. The transport pathways of luminal and at least initially soluble secretory proteins synthesized in the endoplasmic reticulum can be… read more here.
Keywords: cell; regulated secretion; goblet; intracellular transport ... See more keywords