In vivo imaging of calcium and glutamate responses to intracortical microstimulation reveals distinct temporal responses of the neuropil and somatic compartments in layer II/III neurons.
Sign Up to like & getrecommendations! Published in 2020 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2020.119767
Abstract: OBJECTIVE Intracortical microelectrode implants can generate a tissue response hallmarked by glial scarring and neuron cell death within 100-150 μm of the biomaterial device. Many have proposed that any performance decline in intracortical microstimulation (ICMS) due… read more here.
Keywords: stimulation; layer iii; calcium; intracortical microstimulation ... See more keywords
The temporal pattern of intracortical microstimulation pulses elicits distinct temporal and spatial recruitment of cortical neuropil and neurons
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neural Engineering"
DOI: 10.1088/1741-2552/abc29c
Abstract: Objective. The temporal spacing or distribution of stimulation pulses in therapeutic neurostimulation waveforms—referred to here as the Temporal Pattern (TP)—has emerged as an important parameter for tuning the response to deep-brain stimulation and intracortical microstimulation… read more here.
Keywords: icms; response; stimulation; temporal pattern ... See more keywords
Intracortical microstimulation pulse waveform and frequency recruits distinct spatiotemporal patterns of cortical neuron and neuropil activation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neural Engineering"
DOI: 10.1088/1741-2552/ac5bf5
Abstract: Objective. Neural prosthetics often use intracortical microstimulation (ICMS) for sensory restoration. To restore natural and functional feedback, we must first understand how stimulation parameters influence the recruitment of neural populations. ICMS waveform asymmetry modulates the… read more here.
Keywords: activation; intracortical microstimulation; activity; stimulation ... See more keywords
Intracortical Microstimulation Maps of Motor, Somatosensory, and Posterior Parietal Cortex in Tree Shrews (Tupaia belangeri) Reveal Complex Movement Representations
Sign Up to like & getrecommendations! Published in 2017 at "Cerebral Cortex"
DOI: 10.1093/cercor/bhv329
Abstract: Abstract Long‐train intracortical microstimulation (LT‐ICMS) is a popular method for studying the organization of motor and posterior parietal cortex (PPC) in mammals. In primates, LT‐ICMS evokes both multijoint and multiple‐body‐part movements in primary motor, premotor,… read more here.
Keywords: tree shrews; cortex; complex movement; motor ... See more keywords
Responses of Cortical Neurons to Intracortical Microstimulation in Awake Primates
Sign Up to like & getrecommendations! Published in 2022 at "eNeuro"
DOI: 10.1523/eneuro.0336-22.2023
Abstract: Abstract Intracortical microstimulation (ICMS) is commonly used in many experimental and clinical paradigms; however, its effects on the activation of neurons are still not completely understood. To document the responses of cortical neurons in awake… read more here.
Keywords: neurons intracortical; intracortical microstimulation; responses cortical; stimulation ... See more keywords