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Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4022
Abstract: Introduction: NVL-655 is a brain-penetrant, ALK-selective tyrosine kinase inhibitor (TKI) designed to maintain activity against ALK and ALK mutations that confer resistance to currently approved therapies, and to avoid neurological adverse events and dose-limiting toxicities…
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Keywords:
intracranial activity;
nvl 655;
eml4 alk;
alk ... See more keywords
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Published in 2021 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2021.39.15_suppl.9084
Abstract: 9084 Background: Brain metastases (BMs) are reported in 20–40% of pts with METex14 skipping NSCLC and present a high unmet need with poor prognosis. Tepotinib is a highly selective MET inhibitor that has demonstrated intracranial…
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Keywords:
tepotinib;
skipping nsclc;
intracranial activity;
activity ... See more keywords