MicroRNA-profiling of miR-371~373- and miR-302/367-clusters in serum and cerebrospinal fluid identify patients with intracranial germ cell tumors
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DOI: 10.1007/s00432-022-03915-4
Abstract: Intracranial germ cell tumors (iGCT) comprise germinoma and non-germinoma. Their diagnosis predominantly relies on biopsy as only one-fifth of patients present with elevated biomarkers (AFP/ß-HCG) in serum or cerebrospinal fluid (CSF). MicroRNAs (miR/miRNA) have emerged… read more here.
Keywords: germ cell; usepackage; mir; intracranial germ ... See more keywords
[Intracranial germ cell tumours: A 21-year review].
Sign Up to like & getrecommendations! Published in 2017 at "Anales de pediatria"
DOI: 10.1016/j.anpedi.2016.03.005
Abstract: INTRODUCTION Intracranial germ cell tumours are rare in children. They are a heterogeneous group of neoplasms that show different clinical manifestations despite having a common origin. PATIENTS AND METHODS A retrospective analysis was carried out… read more here.
Keywords: intracranial germ; cell tumours; germ cell; diagnosis ... See more keywords
GCT-31. DIAGNOSTIC CAPABILITY OF CSF-PLAP ON INTRACRANIAL GERM CELL TUMOR
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DOI: 10.1093/neuonc/noaa222.251
Abstract: Abstract BACKGROUND Since the majority of intracranial germ cell tumor(GCT) is sensitive for chemoradiation, biopsy specimens are usually tiny and not enough for accurate pathological diagnosis. To supply complementary diagnostic information, a-fetoprotein or human chorionic… read more here.
Keywords: intracranial germ; value; csf plap; tumor ... See more keywords
GCT-57. ARE MELATONIN LEVELS A RELIABLE MARKER FOR INTRACRANIAL GERM CELL TUMORS POST TREATMENT DEFICIENCY?
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DOI: 10.1093/neuonc/noaa222.274
Abstract: Abstract BACKGROUND Pineal is the melatonin-producing gland, with this hormone importantly acting as a central and peripheral chronobiotic, antioxidant and in energy metabolism. The urinary dosage of 6-sulfatoxymelatonin (aMT6s), a melatonin metabolite, is an indirect… read more here.
Keywords: marker; germ cell; melatonin; intracranial germ ... See more keywords
QOL-25. MICROSTRUCTURAL BRAIN CHANGES ASSOCIATED WITH NEUROCOGNITIVE AND FUNCTIONAL OUTCOMES OF INTRACRANIAL GERM CELL TUMUOR SURVIVORS – A DIFFUSIONAL KURTOSIS IMAGING STUDY
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DOI: 10.1093/neuonc/noaa222.687
Abstract: Abstract BACKGROUND Childhood intracranial germ cell tumour (iGCT) survivors are prone to radiotherapy-related neurotoxicity which can lead to neurocognitive dysfunction. Diffusion kurtosis imaging (DKI) is a MRI technique that quantifies microstructural changes in the grey… read more here.
Keywords: study; brain; changes associated; kurtosis ... See more keywords
Intracranial germ cell tumors in Adolescents and Young Adults: European and North American consensus review, current management and future development.
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DOI: 10.1093/neuonc/noab252
Abstract: The incidence of intracranial germ cell tumors (iCGT) is much lower in European and North American (E&NA) than in Asian population. However, E&NA cooperative groups have successfully developed in parallel treatment strategies with specific attention… read more here.
Keywords: european north; north american; germ cell; intracranial germ ... See more keywords
GERM-02. IMMUNOHISTOCHEMICAL EVALUATION FOR THE PATHOGENESIS OF INTRACRANIAL GERM CELL TUMORS: EXPRESSION OF PLURIPOTENCY AND CELL DIFFERENTIATION MARKERS.
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DOI: 10.1093/neuonc/nox083.088
Abstract: Abstract INTRODUCTION: Primary intracranial germ cell tumors (iGCT) are rare neoplasms that occur in children and adolescents. This study examined both the pathogenesis and the origin of these tumors, as it has been hypothesized that… read more here.
Keywords: cell; pathogenesis; germ; germ cell ... See more keywords
Carboplatin-based regimen in pediatric intracranial germ-cell tumors (IC-GCTs): effectiveness and ototoxicity.
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DOI: 10.1093/nop/npz043
Abstract: Background Induction chemotherapy with carboplatin followed by radiotherapy has been used for many years for treating intracranial germ-cell tumors (IC-GCTs) in Thailand. The objective of this study was to assess treatment outcomes, focusing on survival… read more here.
Keywords: ototoxicity; germ cell; carboplatin; intracranial germ ... See more keywords
A pragmatic diagnostic approach to primary intracranial germ cell tumors and their treatment outcomes
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DOI: 10.2217/cns-2021-0012
Abstract: Background: Primary intracranial germ cell tumors (ICGCT) are often diagnosed with tumor markers and imaging, which may avoid the need for a biopsy. An intracranial germ cell tumor with mild elevation of markers is seldom… read more here.
Keywords: primary intracranial; intracranial germ; cell tumors; germ cell ... See more keywords
Intracranial Germ Cell Tumor in the Molecular Era
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DOI: 10.3340/jkns.2018.0056
Abstract: Intracranial germ cell tumors (iGCTs) are a heterogeneous group of tumors with peculiar characteristics clearly distinguished from other brain tumors of neuroepithelial origin. Diverse histology, similarity to gonadal GCT, predilection to one sex, and geographic… read more here.
Keywords: tumor molecular; intracranial germ; cell tumor; germ cell ... See more keywords
Brain Microstructural Changes Associated With Neurocognitive Outcome in Intracranial Germ Cell Tumor Survivors
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DOI: 10.3389/fonc.2021.573798
Abstract: Background Childhood intracranial germ cell tumor (GCT) survivors are prone to radiotherapy-related neurotoxicity, which can lead to neurocognitive dysfunctions. Diffusion kurtosis imaging (DKI) is a diffusion MRI technique that is sensitive to brain microstructural changes.… read more here.
Keywords: microstructural changes; matter; gct survivors; intracranial germ ... See more keywords