Catalytic-Independent Functions of PARP-1 Determine Sox2 Pioneer Activity at Intractable Genomic Loci.
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DOI: 10.1016/j.molcel.2017.01.017
Abstract: Pioneer transcription factors (TFs) function as genomic first responders, binding to inaccessible regions of chromatin to promote enhancer formation. The mechanism by which pioneer TFs gain access to chromatin remains an important unanswered question. Here… read more here.
Keywords: pioneer activity; genomic loci; intractable genomic; activity ... See more keywords