Neutrophils, eosinophils and intraepithelial lymphocytes in the squamous esophagus in subjects with and without gastroesophageal reflux symptoms.
Sign Up to like & getrecommendations! Published in 2021 at "Human pathology"
DOI: 10.1016/j.humpath.2021.06.004
Abstract: BACKGROUND Whilst intraepithelial lymphocytes (IELs) are considered normal within the distal esophageal mucosa, there is an appreciation of the potential role of excess lymphocytic infiltration in the pathogenesis of mucosal damage in reflux esophagitis. Furthermore,… read more here.
Keywords: intraepithelial lymphocytes; reflux; esophageal mucosa; upper limit ... See more keywords
Porcine intraepithelial lymphocytes undergo migration and produce an antiviral response following intestinal virus infection.
Sign Up to like & getrecommendations! Published in 2022 at "Communications biology"
DOI: 10.1038/s42003-022-03205-2
Abstract: The location of intraepithelial lymphocytes (IELs) between epithelial cells provide a first line of immune defense against enteric infection. It is assumed that IELs migrate only along the basement membrane or into the lateral intercellular… read more here.
Keywords: porcine; intraepithelial lymphocytes; antiviral response; infection ... See more keywords
γδ intraepithelial lymphocytes facilitate pathological epithelial cell shedding via CD103-mediated granzyme release.
Sign Up to like & getrecommendations! Published in 2021 at "Gastroenterology"
DOI: 10.1053/j.gastro.2021.11.028
Abstract: BACKGROUND & AIMS Excessive shedding of apoptotic enterocytes into the intestinal lumen is observed in inflammatory bowel disease and is correlated with disease relapse. Based on their cytolytic capacity and surveillance behavior, we investigated whether… read more here.
Keywords: release; intraepithelial lymphocytes; microscopy; cd103 ... See more keywords
Counting Intraepithelial Lymphocytes: A Comparison Between Routine Staining and CD3 Immunohistochemistry
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Surgical Pathology"
DOI: 10.1177/1066896919894644
Abstract: Counting intraepithelial lymphocytes (IELs) is a key part of the assessment of duodenal biopsies. Immunohistochemistry (IHC) for CD3 can aid identification of lymphocytes in this context, but it is not evident that counts on hematoxylin… read more here.
Keywords: cd3 ihc; intraepithelial lymphocytes; cd3; lymphocytes comparison ... See more keywords
Dominant Negative FADD/MORT1 Inhibits the Development of Intestinal Intraepithelial Lymphocytes With a Marked Defect on CD8αα+TCRγδ+ T Cells
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.02038
Abstract: Intestinal intraepithelial lymphocytes (IELs) play a critical role in mucosal immune system, which differ from thymus-derived cells and develop locally in gut. Although the development of IELs has been studied in some detail, the molecular… read more here.
Keywords: intraepithelial lymphocytes; dominant negative; development intestinal; intestinal intraepithelial ... See more keywords
Identification and Regulation of TCRαβ+CD8αα+ Intraepithelial Lymphocytes in Murine Oral Mucosa
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2020.01702
Abstract: TCRαβ+CD8αα+ intraepithelial lymphocytes (IELs) are abundant in gastrointestinal (GI) tract and play an important role in regulation of mucosal immunity and tolerance in the gut. However, it is unknown whether TCRαβ+CD8αα+ IELs exist in the… read more here.
Keywords: intraepithelial lymphocytes; tcr cd8; cd8 intraepithelial; oral mucosa ... See more keywords
Intraepithelial lymphocytes in the pig intestine: T cell and innate lymphoid cell contributions to intestinal barrier immunity
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1048708
Abstract: Intraepithelial lymphocytes (IELs) include T cells and innate lymphoid cells that are important mediators of intestinal immunity and barrier defense, yet most knowledge of IELs is derived from the study of humans and rodent models.… read more here.
Keywords: cell; intestine; barrier; immunity ... See more keywords
Conjunctival Intraepithelial Lymphocytes, Lacrimal Cytokines and Ocular Commensal Microbiota: Analysis of the Three Main Players in Allergic Conjunctivitis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.911022
Abstract: Conjunctival intraepithelial lymphocytes, tear soluble molecules and commensal microbiota have important roles in the ocular mucosal immune response in healthy and diseased subjects. For the purpose of this study, the cellular and microbial populations of… read more here.
Keywords: commensal microbiota; allergic conjunctivitis; conjunctivitis; perennial allergic ... See more keywords
Enterovirus 71 Antagonizes Antiviral Effects of Type III Interferon and Evades the Clearance of Intestinal Intraepithelial Lymphocytes
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2021.806084
Abstract: Enterovirus 71 (EV71) is the major pathogen causing severe neurological complications and hand, foot, and mouth disease. The intestinal mucosal immune system has a complete immune response and immune regulation mechanism, consisting of densely arranged… read more here.
Keywords: type iii; infection; intestinal mucosal; intestinal intraepithelial ... See more keywords