Ciliary dynein arms: Cytoplasmic preassembly, intraflagellar transport, and axonemal docking
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30689
Abstract: The microtubular scaffold of motile cilia—the axoneme, is decorated with dynein arms, which are large multiprotein complexes essential for ciliary motility. Dynein arms are arranged along the length of the axoneme in a precise repeating… read more here.
Keywords: intraflagellar transport; dynein arms; preassembly intraflagellar; cytoplasmic preassembly ... See more keywords
C11orf70 Mutations Disrupting the Intraflagellar Transport-Dependent Assembly of Multiple Axonemal Dyneins Cause Primary Ciliary Dyskinesia.
Sign Up to like & getrecommendations! Published in 2018 at "American journal of human genetics"
DOI: 10.1016/j.ajhg.2018.03.024
Abstract: Primary ciliary dyskinesia (PCD) is a genetically and phenotypically heterogeneous disorder characterized by destructive respiratory disease and laterality abnormalities due to randomized left-right body asymmetry. PCD is mostly caused by mutations affecting the core axoneme… read more here.
Keywords: primary ciliary; ciliary dyskinesia; intraflagellar transport; transport ... See more keywords
The microgravity induces the ciliary shortening and an increased ratio of anterograde/retrograde intraflagellar transport of osteocytes.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.06.119
Abstract: It is hard to explain the decrease in mechanosensitivity of osteocytes under microgravity. Primary cilia are essential mechanosensor for osteocytes. The cilia become shorter under the simulated microgravity (SMG) environment. The cilia change may be… read more here.
Keywords: intraflagellar transport; anterograde retrograde; microgravity; ift particles ... See more keywords
Intraflagellar Transport Complex B Proteins Regulate the Hippo Effector Yap1 during Cardiogenesis.
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.107932
Abstract: Cilia and the intraflagellar transport (IFT) proteins involved in ciliogenesis are associated with congenital heart diseases (CHDs). However, the molecular links between cilia, IFT proteins, and cardiogenesis are yet to be established. Using a combination… read more here.
Keywords: transport complex; complex proteins; effector yap1; intraflagellar transport ... See more keywords
Genetic reduction of cilium-length by targeting intraflagellar transport 88 protein impedes kidney and liver cysts formation in mouse models of autosomal polycystic kidney disease.
Sign Up to like & getrecommendations! Published in 2020 at "Kidney international"
DOI: 10.1016/j.kint.2020.05.049
Abstract: Polycystin-1 (PC1) and -2 (PC2), products of the PKD1 and PKD2 genes, are mutated in autosomal dominant polycystic kidney disease (ADPKD). They localize to the primary cilia; however, their ciliary function is in dispute. Loss… read more here.
Keywords: kidney; intraflagellar transport; cilium length; disease ... See more keywords
Intraflagellar transport 46 (IFT46) is essential for trafficking IFT proteins between cilia and cytoplasm in Paramecium
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-27050-8
Abstract: Intraflagellar transport (IFT) is a bi-directional process by which particles are carried within the cilia or flagella. This process is essential for ciliary growth and functional maintenance. The IFT complex B (IFTB) is linked to… read more here.
Keywords: trafficking ift; paramecium; intraflagellar transport; transport ... See more keywords
Intraflagellar transport proteins are involved in thrombocyte filopodia formation and secretion
Sign Up to like & getrecommendations! Published in 2018 at "Platelets"
DOI: 10.1080/09537104.2017.1361524
Abstract: Abstract Intraflagellar transport (IFT) proteins are vital for the genesis and maintenance of cilia. Our identification of ift122 transcripts in zebrafish thrombocytes that lack primary cilia was unexpected. IFT proteins serve transport in cilia, whose… read more here.
Keywords: secretion; proteins involved; filopodia; intraflagellar transport ... See more keywords
Hypoxia-Inducible Factor-2alpha Affects the MEK/ERK Signaling Pathway via Primary Cilia in Connection with the Intraflagellar Transport Protein 88 Homolog
Sign Up to like & getrecommendations! Published in 2023 at "Molecular and Cellular Biology"
DOI: 10.1080/10985549.2023.2198931
Abstract: Abstract The ability of cells to communicate with their surrounding is a prerequisite for essential processes such as proliferation, apoptosis, migration, and differentiation. To this purpose, primary cilia serve as antennae-like structures on the surface… read more here.
Keywords: transport protein; intraflagellar transport; hypoxia; factor ... See more keywords
Protein turnover dynamics suggest a diffusion-to-capture mechanism for peri-basal body recruitment and retention of intraflagellar transport proteins
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e20-11-0717
Abstract: Intraflagellar transport (IFT) is essential for construction and maintenance of cilia. IFT proteins concentrate at the basal body where they are thought to assemble into trains and bind cargoes for transport. To study the mechanisms… read more here.
Keywords: body; body recruitment; basal body; ift ... See more keywords
BROMI/TBC1D32 together with CCRK/CDK20 and FAM149B1/JBTS36 contributes to intraflagellar transport turnaround involving ICK/CILK1
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e22-03-0089
Abstract: Primary cilia are antenna-like organelles that contain specific proteins, and are crucial for tissue morphogenesis. Anterograde and retrograde trafficking of ciliary proteins are mediated by the intraflagellar transport (IFT) machinery. BROMI/TBC1D32 interacts with CCRK/CDK20, which… read more here.
Keywords: intraflagellar transport; ccrk cdk20; bromi tbc1d32; fam149b1 ... See more keywords
Integrative modeling reveals the molecular architecture of the intraflagellar transport A (IFT-A) complex
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.07.05.498886
Abstract: Intraflagellar transport (IFT) is a conserved process of cargo transport in cilia that is essential for development and homeostasis in organisms ranging from algae to vertebrates. In humans, variants in genes encoding subunits of the… read more here.
Keywords: intraflagellar transport; transport ift; ift complex; transport ... See more keywords