Quantification of intrahepatic cccDNA in HBV associated hepatocellular carcinoma by improved ddPCR method.
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DOI: 10.1016/j.jviromet.2021.114334
Abstract: The quantification of intrahepatic covalently closed circular DNA (cccDNA) is important for assessing the efficiency of anti-HBV therapy. Exonuclease treatment is essential before real-time quantitative PCR (qPCR) or droplet digital PCR (ddPCR) measurement to improve… read more here.
Keywords: cccdna; intrahepatic cccdna; exonuclease; quantification ... See more keywords
Serum HBV RNA correlated with intrahepatic cccDNA more strongly than other HBV markers during peg-interferon treatment
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DOI: 10.1186/s12985-020-01471-2
Abstract: Background Serum hepatitis B virus RNA (HBV RNA) has been reported to be a surrogate marker of intrahepatic cccDNA during nucleos(t)ide analogs therapy. However, in HBeAg-positive patients treated with peg-interferon (peg-IFN), whether HBV RNA is… read more here.
Keywords: treatment; hbv rna; hbv; intrahepatic cccdna ... See more keywords
Identification of Potential miRNA-mRNA Regulatory Axis of Intrahepatic cccDNA in Patients with Chronic Hepatitis B Virus Infection in the Grey Zone
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DOI: 10.5812/hepatmon-133782
Abstract: Background: Intrahepatic covalently closed circular DNA (cccDNA) plays a critical role in the life cycle of the hepatitis B virus (HBV). Growing evidence suggests that microRNAs (miRNAs) may regulate cccDNA expression and contribute to the… read more here.
Keywords: regulatory axis; mirna mrna; hepatitis; intrahepatic cccdna ... See more keywords