Precision N-glycoproteomics reveals elevated LacdiNAc as a novel signature of intrahepatic cholangiocarcinoma.
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DOI: 10.1002/1878-0261.13147
Abstract: Primary liver cancer, mainly comprising hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC), remains a major global health problem. Although ICC is clinically different from HCC, their molecular differences are still largely unclear. In this study,… read more here.
Keywords: precision; hcc; icc hcc; intrahepatic cholangiocarcinoma ... See more keywords
Patients' prognosis of intrahepatic cholangiocarcinoma and combined hepatocellular‐cholangiocarcinoma after resection
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DOI: 10.1002/cam4.2495
Abstract: Combined hepatocellular‐cholangiocarcinoma (cHCC‐CC) and intrahepatic cholangiocarcinoma (ICC) are classified into one category, but comparison of prognosis of the two carcinomas remains controversial. The aim of the current study was to investigate surgical outcomes for patients… read more here.
Keywords: combined hepatocellular; hepatocellular cholangiocarcinoma; intrahepatic cholangiocarcinoma; cholangiocarcinoma ... See more keywords
Impact of portal hypertension on short‐ and long‐term outcomes after liver resection for intrahepatic cholangiocarcinoma: A propensity score matching analysis
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DOI: 10.1002/cam4.4222
Abstract: We explored the impact of clinically significant portal hypertension (CSPH) on short‐ and long‐term outcomes of intrahepatic cholangiocarcinoma (ICC) after liver resection (LR). read more here.
Keywords: long term; liver resection; intrahepatic cholangiocarcinoma; term outcomes ... See more keywords
Impact of cirrhosis on long‐term survival outcomes of patients with intrahepatic cholangiocarcinoma
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DOI: 10.1002/cam4.4740
Abstract: The correlation between cirrhosis and the long‐term oncological outcome in intrahepatic cholangiocarcinoma (ICC) is debatable, and this study aimed to explore the impact of cirrhosis on the long‐term prognosis of patients with ICC. read more here.
Keywords: long term; impact cirrhosis; intrahepatic cholangiocarcinoma; cirrhosis long ... See more keywords
Adequate lymph node dissection is essential for accurate nodal staging in intrahepatic cholangiocarcinoma: A population‐based study
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DOI: 10.1002/cam4.5620
Abstract: To comprehensively investigate the implications of lymph node dissection (LND) and the prognostic impact of the number of lymph node (LN) metastases on survival in intrahepatic cholangiocarcinoma (ICC) using a large‐scale study. read more here.
Keywords: study; intrahepatic cholangiocarcinoma; node dissection; lymph node ... See more keywords
Disparities in curative treatments and outcomes for early stage intrahepatic cholangiocarcinoma in the United States
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DOI: 10.1002/cncr.34436
Abstract: Curative surgical treatments afford the best prognosis for patients with intrahepatic cholangiocarcinoma (iCCA); however, the comparative effectiveness of treatment options and factors associated with curative treatment receipt for early stage iCCA remain unknown. read more here.
Keywords: early stage; curative treatments; intrahepatic cholangiocarcinoma; disparities curative ... See more keywords
The clinicopathological significance and relapse predictive role of tumor microenvironment of intrahepatic cholangiocarcinoma after radical surgery
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DOI: 10.1002/cncr.34552
Abstract: This study attempts to detect the expression of FoxP3, CD68, CD8α, and PD‐L1 in the tumor microenvironment (TME) of intrahepatic cholangiocarcinoma (ICC), and analyze the relationship between the corresponding cells and clinicopathological characteristics as well… read more here.
Keywords: clinicopathological significance; significance relapse; intrahepatic cholangiocarcinoma; tumor microenvironment ... See more keywords
Phosphorylation and Stabilization of PIN1 by JNK Promote Intrahepatic Cholangiocarcinoma Growth
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DOI: 10.1002/hep.31983
Abstract: Intrahepatic cholangiocarcinoma (ICC) is a highly aggressive type of liver cancer in urgent need of treatment options. Aberrant activation of the c‐Jun N‐terminal kinase (JNK) pathway is a key feature in ICC and an attractive… read more here.
Keywords: phosphorylation stabilization; jnk; intrahepatic cholangiocarcinoma; stabilization pin1 ... See more keywords
The Immunogenomic Landscape of Resected Intrahepatic Cholangiocarcinoma.
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DOI: 10.1002/hep.32150
Abstract: Cholangiocarcinoma is a deadly and highly therapy-refractory cancer of the bile ducts, with early results from immune checkpoint blockade trials showing limited responses. While recent molecular assessments have made bulk characterizations of immune profiles and… read more here.
Keywords: immune checkpoint; immunogenomic landscape; intrahepatic cholangiocarcinoma; resected intrahepatic ... See more keywords
Genomic evolution and the impact of SLIT2 mutation in relapsed intrahepatic cholangiocarcinoma.
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DOI: 10.1002/hep.32164
Abstract: BACKGROUND & AIMS Intrahepatic cholangiocarcinoma (ICC) is aggressive and has high rates of relapse, conferring poor long-term survival after curative resection. Little is known about the genomic evolution that occurs during ICC relapse. APPROACH &… read more here.
Keywords: evolution; intrahepatic cholangiocarcinoma; genomic evolution; mutation ... See more keywords
Molecular and radiopathologic spectrum between HCC and intrahepatic cholangiocarcinoma
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DOI: 10.1002/hep.32397
Abstract: Background and Aims: Primary liver cancers (LCs), including HCC and intrahepatic cholangiocarcinoma (iCCA), are derived from a common developmental lineage, conferring a molecular spectrum between them. To elucidate the molecular spectrum, we performed an integrative… read more here.
Keywords: intrahepatic cholangiocarcinoma; radiopathologic; hcc; hcc intrahepatic ... See more keywords