Precision N-glycoproteomics reveals elevated LacdiNAc as a novel signature of intrahepatic cholangiocarcinoma.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular oncology"
DOI: 10.1002/1878-0261.13147
Abstract: Primary liver cancer, mainly comprising hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC), remains a major global health problem. Although ICC is clinically different from HCC, their molecular differences are still largely unclear. In this study,… read more here.
Keywords: precision; hcc; icc hcc; intrahepatic cholangiocarcinoma ... See more keywords
CircUGP2 Suppresses Intrahepatic Cholangiocarcinoma Progression via p53 Signaling Through Interacting With PURB to Regulate ADGRB1 Transcription and Sponging miR‐3191‐5p
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202402329
Abstract: Intrahepatic cholangiocarcinoma (ICC) is the second most common primary liver cancer and its prognosis remains poor. Although growing numbers of studies have verified the involvement of circular RNAs (circRNAs) in various cancer types, their specific… read more here.
Keywords: progression; p53; intrahepatic cholangiocarcinoma; sponging mir ... See more keywords
A Novel 167‐Amino Acid Protein Encoded by CircPCSK6 Inhibits Intrahepatic Cholangiocarcinoma Progression via IKBα Ubiquitination
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DOI: 10.1002/advs.202409173
Abstract: Intrahepatic cholangiocarcinoma (ICC), a formidable challenge in oncology, demands innovative biomarkers and therapeutic targets. This research highlights the importance of the circular RNA (circRNA) circPCSK6 and its peptide derivative circPCSK6‐167aa in ICC. CircPCSK6 is significantly… read more here.
Keywords: circpcsk6; ubiquitination; intrahepatic cholangiocarcinoma; circpcsk6 167aa ... See more keywords
Single‐Cell and Spatial Transcriptomics Delineate the Microstructure and Immune Landscape of Intrahepatic Cholangiocarcinoma in the Leading‐Edge Area
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DOI: 10.1002/advs.202412740
Abstract: Intrahepatic cholangiocarcinoma (ICC) tumor cells and their interactions with the immune microenvironment, particularly at the leading‐edge area, have been underexplored. This study employs single‐cell RNA sequencing (scRNA‐seq) and spatial transcriptome (ST) analysis on samples from… read more here.
Keywords: intrahepatic cholangiocarcinoma; edge area; leading edge; single cell ... See more keywords
Patients' prognosis of intrahepatic cholangiocarcinoma and combined hepatocellular‐cholangiocarcinoma after resection
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DOI: 10.1002/cam4.2495
Abstract: Combined hepatocellular‐cholangiocarcinoma (cHCC‐CC) and intrahepatic cholangiocarcinoma (ICC) are classified into one category, but comparison of prognosis of the two carcinomas remains controversial. The aim of the current study was to investigate surgical outcomes for patients… read more here.
Keywords: combined hepatocellular; hepatocellular cholangiocarcinoma; intrahepatic cholangiocarcinoma; cholangiocarcinoma ... See more keywords
Impact of portal hypertension on short‐ and long‐term outcomes after liver resection for intrahepatic cholangiocarcinoma: A propensity score matching analysis
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Medicine"
DOI: 10.1002/cam4.4222
Abstract: We explored the impact of clinically significant portal hypertension (CSPH) on short‐ and long‐term outcomes of intrahepatic cholangiocarcinoma (ICC) after liver resection (LR). read more here.
Keywords: long term; liver resection; intrahepatic cholangiocarcinoma; term outcomes ... See more keywords
Impact of cirrhosis on long‐term survival outcomes of patients with intrahepatic cholangiocarcinoma
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DOI: 10.1002/cam4.4740
Abstract: The correlation between cirrhosis and the long‐term oncological outcome in intrahepatic cholangiocarcinoma (ICC) is debatable, and this study aimed to explore the impact of cirrhosis on the long‐term prognosis of patients with ICC. read more here.
Keywords: long term; impact cirrhosis; intrahepatic cholangiocarcinoma; cirrhosis long ... See more keywords
Adequate lymph node dissection is essential for accurate nodal staging in intrahepatic cholangiocarcinoma: A population‐based study
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DOI: 10.1002/cam4.5620
Abstract: To comprehensively investigate the implications of lymph node dissection (LND) and the prognostic impact of the number of lymph node (LN) metastases on survival in intrahepatic cholangiocarcinoma (ICC) using a large‐scale study. read more here.
Keywords: study; intrahepatic cholangiocarcinoma; node dissection; lymph node ... See more keywords
Disparities in curative treatments and outcomes for early stage intrahepatic cholangiocarcinoma in the United States
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DOI: 10.1002/cncr.34436
Abstract: Curative surgical treatments afford the best prognosis for patients with intrahepatic cholangiocarcinoma (iCCA); however, the comparative effectiveness of treatment options and factors associated with curative treatment receipt for early stage iCCA remain unknown. read more here.
Keywords: early stage; curative treatments; intrahepatic cholangiocarcinoma; disparities curative ... See more keywords
The clinicopathological significance and relapse predictive role of tumor microenvironment of intrahepatic cholangiocarcinoma after radical surgery
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DOI: 10.1002/cncr.34552
Abstract: This study attempts to detect the expression of FoxP3, CD68, CD8α, and PD‐L1 in the tumor microenvironment (TME) of intrahepatic cholangiocarcinoma (ICC), and analyze the relationship between the corresponding cells and clinicopathological characteristics as well… read more here.
Keywords: clinicopathological significance; significance relapse; intrahepatic cholangiocarcinoma; tumor microenvironment ... See more keywords
Phosphorylation and Stabilization of PIN1 by JNK Promote Intrahepatic Cholangiocarcinoma Growth
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DOI: 10.1002/hep.31983
Abstract: Intrahepatic cholangiocarcinoma (ICC) is a highly aggressive type of liver cancer in urgent need of treatment options. Aberrant activation of the c‐Jun N‐terminal kinase (JNK) pathway is a key feature in ICC and an attractive… read more here.
Keywords: phosphorylation stabilization; jnk; intrahepatic cholangiocarcinoma; stabilization pin1 ... See more keywords