Metformin reduces intrahepatic fibrosis and intrapulmonary shunts in biliary cirrhotic rats
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DOI: 10.1016/j.jcma.2017.05.005
Abstract: Background Liver fibrosis causes portal hypertension which dilates collateral vasculature and enhances extra‐hepatic angiogenesis including intrapulmonary shunts, which subsequently complicates with hepatopulmonary syndrome. Metformin is an anti‐diabetic agent which possesses anti‐inflammation and anti‐angiogenesis properties. This… read more here.
Keywords: intrapulmonary shunts; fibrosis; angiogenesis; intrahepatic fibrosis ... See more keywords