Intramembrane Nanoaggregates of Antimicrobial Peptides Play a Vital Role in Bacterial Killing.
Sign Up to like & getrecommendations! Published in 2022 at "Small"
DOI: 10.1002/smll.202204428
Abstract: Recent developments in antimicrobial peptides (AMPs) have focused on the rational design of short sequences with less than 20 amino acids due to their relatively low synthesis costs and ease of correlation of the structure-function… read more here.
Keywords: antimicrobial peptides; antimicrobial efficacy; intramembrane; nanoaggregates antimicrobial ... See more keywords
Expression and Purification of Human Mitochondrial Intramembrane Protease PARL.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1394-8_1
Abstract: Rhomboid proteases are a ubiquitous superfamily of serine intramembrane peptidases that play a role in a wide variety of cellular processes. The mammalian mitochondrial rhomboid protease, Presenilin-Associated Rhomboid Like (PARL), is a critical regulator of… read more here.
Keywords: protease; intramembrane; expression; purification human ... See more keywords
Intramembrane proteolysis at a glance: from signalling to protein degradation
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cell Science"
DOI: 10.1242/jcs.217745
Abstract: ABSTRACT Over the last two decades, a group of unusual proteases, so-called intramembrane proteases, have become increasingly recognized for their unique ability to cleave peptide bonds within cellular membranes. They are found in all kingdoms… read more here.
Keywords: degradation; intramembrane; glance; intramembrane proteolysis ... See more keywords
Intramembrane protease RHBDL4 cleaves oligosaccharyltransferase subunits to target them for ER-associated degradation
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cell Science"
DOI: 10.1242/jcs.243790
Abstract: ABSTRACT The endoplasmic reticulum (ER)-resident intramembrane rhomboid protease RHBDL4 generates metastable protein fragments and together with the ER-associated degradation (ERAD) machinery provides a clearance mechanism for aberrant and surplus proteins. However, the endogenous substrate spectrum… read more here.
Keywords: rhbdl4; protease rhbdl4; associated degradation; intramembrane ... See more keywords
Mutational re-modeling of di-aspartyl intramembrane proteases: uncoupling physiologically-relevant activities from those associated with Alzheimer's disease.
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.18299
Abstract: The intramembrane proteolytic activities of presenilins (PSEN1/PS1 and PSEN2/PS2) underlie production of β-amyloid, the key process in Alzheimer's disease (AD). Dysregulation of presenilin-mediated signaling is linked to cancers. Inhibition of the γ-cleavage activities of PSENs… read more here.
Keywords: cleavage; alzheimer disease; intramembrane; aspartyl ... See more keywords