EGFR-Dependent Regulated Intramembrane Proteolysis of EpCAM-Letter.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer research"
DOI: 10.1158/0008-5472.can-16-2456
Abstract: Hsu and colleagues reported on EGF/EGFR–triggered activation of regulated intramembrane proteolysis (RIP) of EpCAM that induces an EMT phenotype ([1][1]). This finding is of utmost interest, as it might explain contradicting effects of EpCAM on… read more here.
Keywords: egfr dependent; dependent regulated; intramembrane proteolysis; epcam ... See more keywords
Intramembrane proteolysis at a glance: from signalling to protein degradation
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DOI: 10.1242/jcs.217745
Abstract: ABSTRACT Over the last two decades, a group of unusual proteases, so-called intramembrane proteases, have become increasingly recognized for their unique ability to cleave peptide bonds within cellular membranes. They are found in all kingdoms… read more here.
Keywords: degradation; intramembrane; glance; intramembrane proteolysis ... See more keywords
Covalent fragment inhibits intramembrane proteolysis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.958399
Abstract: Alzheimer’s disease (AD) is a serious public health crisis with only one current modifying treatment. The reduction of amyloid load by targeting γ-secretase (GS) has been a leading approach in AD drug discovery and development.… read more here.
Keywords: fragment inhibits; covalent fragment; intramembrane proteolysis; inhibits intramembrane ... See more keywords