Intramolecular Addition of Heteroaryllithium Compounds onto Activated Alkenes: Access to Heterofused Indolizines and Pyrroloazepines
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.201700123
Abstract: Heteroaryllithium compounds, obtained by MesLi-mediated halogen/lithium exchange, undergo intramolecular addition onto acrylamide and acrylate moieties. Both electron-rich (thiophenyl) and electron-deficient (pyridinyl, quinolinyl) heteroaromatic halides can be used for the formation of six- and seven-membered rings,… read more here.
Keywords: addition heteroaryllithium; indolizines pyrroloazepines; heteroaryllithium compounds; intramolecular addition ... See more keywords
Stereodivergent Palladium- and Rhodium-Catalyzed Intramolecular Addition of Tosylureas to Allenes: Diastereoselective Synthesis of Tetrahydropyrimidinones.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c03482
Abstract: The intramolecular addition of tosylureas to allenes is highly syn-/anti-diastereoselective when employing a palladium or rhodium-based catalytic system and affords 1,3-cyclic ureas. Under palladium catalysis a range of thermodynamic anti-tetrahydropyrimidinones are accessible, while rhodium catalysis… read more here.
Keywords: rhodium; intramolecular addition; palladium rhodium; tosylureas allenes ... See more keywords
Computational insights into the mechanisms of Au(I)-catalysed intramolecular addition of the hydroxylamine group onto alkynes
Sign Up to like & getrecommendations! Published in 2017 at "Organic chemistry frontiers"
DOI: 10.1039/c7qo00072c
Abstract: Computational studies were carried out to understand the reaction mechanisms and the origin of the substrate-dependent chemo- and regio-selectivities of the Au(I)-catalysed intramolecular addition of the hydroxylamine group onto alkynes. For the terminal and the… read more here.
Keywords: addition hydroxylamine; intramolecular addition; group onto; onto alkynes ... See more keywords
Pd-Catalyzed intramolecular C–H addition to the cyano-group: construction of functionalized 2,3-fused thiophene scaffolds
Sign Up to like & getrecommendations! Published in 2018 at "Organic chemistry frontiers"
DOI: 10.1039/c7qo01000a
Abstract: An efficient synthesis of 2,3-fused thiophenes was demonstrated through a Pd-catalyzed intramolecular C–H addition of thiophenes bearing cyanohydrin components at the C(3) positions to nitriles. A diversity of functionalized fused thiophenes with saturated six-, seven-… read more here.
Keywords: addition cyano; intramolecular addition; cyano group; functionalized fused ... See more keywords
Base-Promoted Intramolecular Addition of Vinyl Cyclopropanecarboxamides to Access Conformationally Restricted Aza[3.1.0]bicycles
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28093691
Abstract: 3-Azabicyclo[3.1.0]hexanes are common structural components in natural products and bioactive compounds. Traditionally, the metal-mediated cyclopropanation domino reaction of chain enzymes is the most commonly used strategy for the construction of this type of aza[3.1.0]bicycle derivative.… read more here.
Keywords: base promoted; aza bicycles; conformationally restricted; promoted intramolecular ... See more keywords