Chiral Brønsted Acid-Catalyzed Intramolecular Asymmetric Allylic Alkylation of Indoles with Primary Alcohols.
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DOI: 10.1021/acs.orglett.2c01253
Abstract: Herein, chiral Brønsted acid-catalyzed intramolecular asymmetric allylic alkylation of indoles with allylic primary alcohols is described. The allyl alcohols were directly employed as the allylic precursors in this metal-free protocol, without preactivation or any additional… read more here.
Keywords: intramolecular asymmetric; catalyzed intramolecular; chiral nsted; nsted acid ... See more keywords
Iridium-Catalyzed Intramolecular Asymmetric Allylation of Vinyl Benzoxazinones for the Synthesis of Chiral 4H-3,1-Benzoxazines via Kinetic Resolution.
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DOI: 10.1021/acs.orglett.3c00148
Abstract: Chiral benzoxazinones and 4H-3,1-benzoxazines as important motifs are widely found in abundant pharmaceuticals and biological molecules. We herein successfully developed the first kinetic resolution (KR) process of racemic benzoxazinones through Ir-catalyzed asymmetric intramolecular allylation, furnishing… read more here.
Keywords: intramolecular asymmetric; catalyzed intramolecular; allylation; iridium catalyzed ... See more keywords