Intramolecular Pd-Catalyzed Reductive Amination of Enolizable sp3-C-H Bonds.
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DOI: 10.1021/acs.orglett.9b03458
Abstract: A palladium-catalyzed reductive cyclization of nitroarenes has been designed to construct sp3-C-NHAr bonds from sp3-C-H bonds by using an enolizable nucleophile to intercept a nitrosoarene intermediate. Exposure of ortho-substituted nitroarenes to 5 mol % of Pd(OAc)2… read more here.
Keywords: intramolecular catalyzed; catalyzed reductive; sp3 bonds; reductive amination ... See more keywords