Stereodivergent Intramolecular Cyclopropanation Enabled by Engineered Carbene Transferases.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b02700
Abstract: We report the development of engineered myoglobin biocatalysts for executing asymmetric intramolecular cyclopropanations resulting in cyclopropane-fused γ-lactones, which are key motifs found in many bioactive molecules. Using this strategy, a broad range of allyl diazoacetate… read more here.
Keywords: cyclopropanation; cyclopropanation enabled; intramolecular cyclopropanation; stereodivergent intramolecular ... See more keywords
Cu(II)-mediated direct intramolecular cyclopropanation of distal olefinic acetate: access to cyclopropane-fused γ-lactone
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DOI: 10.1039/d3sc01752d
Abstract: Cyclopropane-fused ring scaffold represents one of the most appealing structural motifs in organic chemistry due to their wide presence in bioactive molecules and versatility in organic synthesis. These skeletons are... read more here.
Keywords: cyclopropane; mediated direct; cyclopropane fused; intramolecular cyclopropanation ... See more keywords