Interrupted Intramolecular Hydroaminomethylation of N-Protected-2-vinyl Anilines: Novel Access to 3-Substitued Indoles or Indoline-2-ols
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DOI: 10.3390/molecules27031074
Abstract: A new synthetic alternative to the synthesis of 3-methyl indoles and 3-methyl indoline-2-ols with an excellent atomic economy is presented in this study. It is demonstrated that the intramolecular interrupted hydroaminomethylation (HAM) reaction is a… read more here.
Keywords: intramolecular hydroaminomethylation; interrupted intramolecular; indoline ols; protected vinyl ... See more keywords
An Intramolecular Hydroaminomethylation-Based Approach to Pyrrolizidine Alkaloids under Microwave-Assisted Heating
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DOI: 10.3390/molecules27154762
Abstract: A general method for the synthesis of pyrrolizidine derivatives using an intramolecular hydroaminomethylation protocol (HAM) under microwave (MW) dielectric heating is reported. Starting from a 3,4-bis(benzyloxy)-2-[(benzyloxy)methyl]-5-vinylpyrrolidine, MW-assisted intramolecular HAM in the presence of gaseous H2… read more here.
Keywords: intramolecular hydroaminomethylation; heating; pyrrolizidine; hydroaminomethylation based ... See more keywords