Articles with "intramolecular michael" as a keyword



Photo by trnavskauni from unsplash

Chloramphenicol base chemistry. Part 101: Asymmetric synthesis of α-hydroxy chiral alcohols via intramolecular Michael additions of γ-hydroxy-α, β-unsaturated enones with chloramphenicol base derived bifunctional urea organocatalysts

Sign Up to like & get
recommendations!
Published in 2017 at "Tetrahedron"

DOI: 10.1016/j.tet.2017.03.076

Abstract: We have developed the chloramphenicol base urea-catalyzed intramolecular Michael addition of γ-hydroxy-α, β-unsaturated enones. The oxidation of the resulting products provided facile access to the corresponding α-hydroxy chiral alcohols with good efficiency and enantioselectivity, with… read more here.

Keywords: chloramphenicol base; chemistry; hydroxy unsaturated; unsaturated enones ... See more keywords