Pd-catalyzed intramolecular sequential Heck cyclization and oxidation reactions: a facile pathway for the synthesis of substituted cycloheptenone evaluated using computational studies
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DOI: 10.1039/c6nj02694j
Abstract: A simple and convenient method for the construction of substituted cycloheptenones from 1-bromoocta-1,7-diene-3-ols has been developed. The reaction involves Pd(0)-catalyzed intramolecular 7-exo-trig cyclization followed by Pd(II)-catalyzed oxidation of cyclic alcohol. The course of the reaction… read more here.
Keywords: oxidation; cyclization; intramolecular sequential; sequential heck ... See more keywords