Synthesis of 1,4-dihydropyrazolo[4,3-b]indoles via intramolecular C(sp2)-N bond formation involving nitrene insertion, DFT study and their anticancer assessment.
Sign Up to like & getrecommendations! Published in 2021 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2021.105114
Abstract: We herein report a new synthetic route for a series of unreported 1,4-dihydropyrazolo[4,3-b]indoles (6-8) via deoxygenation of o-nitrophenyl-substituted N-aryl pyrazoles and subsequent intramolecular (sp2)-N bond formation under microwave irradiation expedite modified Cadogan condition. This method… read more here.
Keywords: bond formation; intramolecular sp2; indoles via; dft study ... See more keywords
Electrochemical intramolecular N(sp2)–H/N(sp3)–H coupling for the synthesis of 1H-indazoles
Sign Up to like & getrecommendations! Published in 2023 at "Green Chemistry"
DOI: 10.1039/d3gc00380a
Abstract: The electrochemical intramolecular cyclization of ketimines via N–H/N–H dehydrogenation coupling has been established for the construction of 1H-indazole scaffolds. read more here.
Keywords: synthesis indazoles; sp2 sp3; sp3 coupling; coupling synthesis ... See more keywords