Desymmetrization Process by Mg(II)-Catalyzed Intramolecular Vinylogous Michael Reaction.
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DOI: 10.1021/acs.orglett.0c03417
Abstract: Chiral magnesium catalyzed intramolecular vinylogous Michael reaction of novel cyclohexadienones via a desymmetrization process is reported. (R)-BINOL derived ligand and an achiral amide were employed in the current in situ generated magnesium catalyst, giving the… read more here.
Keywords: vinylogous michael; michael reaction; intramolecular vinylogous; desymmetrization process ... See more keywords
Phosphine-Catalyzed Intramolecular Vinylogous Aldol Reaction of α-Substituted Enones.
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DOI: 10.1021/acs.orglett.1c03913
Abstract: We demonstrate the first phosphine-catalyzed intramolecular vinylogous aldol reaction (IVAR) of α-substituted enones. This strategy provides access to various pentannulated (hetero)arenes and dibenzocycloheptanones incorporated with two contiguous stereocenters, one of which is an all-carbon quaternary… read more here.
Keywords: phosphine catalyzed; intramolecular vinylogous; vinylogous aldol; aldol reaction ... See more keywords
Convergent Synthesis of Enantioenriched ortho-Fused Tricyclic Diketones via Catalytic Asymmetric Intramolecular Vinylogous Aldol Condensation.
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DOI: 10.1021/acs.orglett.2c03645
Abstract: Herein, we describe a catalytic asymmetric intramolecular vinylogous aldol reaction by taking advantage of dual organocatalysts, which enables convergent synthesis of ortho-fused tricyclic diketones in excellent enantioselectivities and diastereoselectivities. Noteworthy is that the reaction stereoselectively… read more here.
Keywords: asymmetric intramolecular; ortho fused; convergent synthesis; intramolecular vinylogous ... See more keywords
Enantioselective Synthesis of Functionalized 4-Aryl Hydrocoumarins and 4-Aryl Hydroquinolin-2-ones via Intramolecular Vinylogous Rauhut-Currier Reaction of para-Quinone Methides.
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DOI: 10.1021/acs.orglett.7b01331
Abstract: A novel strategy for the asymmetric construction of functionalized 4-aryl-3,4-dihydrocoumarins and 4-aryl-3,4-dihydroquinolin-2-ones via an intramolecular vinylogous Rauhut-Currier reaction of para-quinone methides (p-QMs) under the bifunctional catalysis of chiral amine-phosphine is described. This intramolecular mode for… read more here.
Keywords: vinylogous rauhut; via intramolecular; ones via; rauhut currier ... See more keywords