Iterative Design of Ionizable Lipids for Intramuscular mRNA Delivery.
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DOI: 10.1021/jacs.2c10670
Abstract: Lipid nanoparticles (LNPs) are the most clinically advanced delivery vehicles for RNA and have enabled the development of RNA-based drugs such as the mRNA COVID-19 vaccines. Functional delivery of mRNA by an LNP greatly depends… read more here.
Keywords: mrna delivery; iterative design; intramuscular mrna; ionizable lipids ... See more keywords