Lipid and Transcriptional Regulation in a Parkinson's Disease Mouse Model by Intranasal Vesicular and Hexosomal Plasmalogen‐Based Nanomedicines
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202304588
Abstract: Plasmalogens (vinyl‐ether phospholipids) are an emergent class of lipid drugs against various diseases involving neuro‐inflammation, oxidative stress, mitochondrial dysfunction, and altered lipid metabolism. They can activate neurotrophic and neuroprotective signaling pathways but low bioavailabilities limit… read more here.
Keywords: transcriptional regulation; vesicular hexosomal; hexosomal plasmalogen; intranasal ... See more keywords
Factors affecting adherence to intranasal treatment for allergic rhinitis: A qualitative study
Sign Up to like & getrecommendations! Published in 2022 at "Laryngoscope Investigative Otolaryngology"
DOI: 10.1002/lio2.986
Abstract: To determine the facilitators of and barriers to adherence to use of intranasal pharmacotherapy (daily intranasal corticosteroids and/or antihistamine, and nasal saline irrigation [NSI]), for allergic rhinitis (AR). read more here.
Keywords: factors affecting; allergic rhinitis; affecting adherence; adherence intranasal ... See more keywords
Intranasal Delivery of Pure Nanodrug Loaded Liposomes for Alzheimer's Disease Treatment by Efficiently Regulating Microglial Polarization.
Sign Up to like & getrecommendations! Published in 2024 at "Small"
DOI: 10.1002/smll.202405781
Abstract: The activated M1-like microglia induced neuroinflammation is the critical pathogenic event in Alzheimer's disease (AD). Microglial polarization from pro-inflammatory M1 toward anti-inflammatory M2 phenotype is a promising strategy. To efficiently accomplish this, amyloid-β (Aβ) aggregates… read more here.
Keywords: alzheimer disease; treatment; microglial polarization; intranasal ... See more keywords
A Feasibility Trial of Home Administration of Intranasal Vaccine by Parents to Eligible Children.
Sign Up to like & getrecommendations! Published in 2017 at "Clinical therapeutics"
DOI: 10.1016/j.clinthera.2016.11.018
Abstract: PURPOSE Intranasal vaccines are being developed for protection against many different infectious agents. The currently available intranasal live attenuated influenza vaccine (LAIV) is only approved for administration by medical personnel. We conducted a pilot study… read more here.
Keywords: laiv; administration; intranasal; home administration ... See more keywords
Nose-to-brain delivery of levetiracetam after intranasal administration to mice.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2019.04.047
Abstract: Despite being one of the most commonly prescribed antiepileptic drugs, levetiracetam is marketed in oral and intravenous dosage forms, which are associated to drug-drug interactions and drug-resistant epilepsy (DRE). The purpose of the present study… read more here.
Keywords: intranasal; levetiracetam; drug; intranasal administration ... See more keywords
P22: Comparative Analysis of Efficacy of Intravenous Ketamine and Intranasal Esketamine in Treatment-Resistant Depression across Age Groups
Sign Up to like & getrecommendations! Published in 2024 at "International Psychogeriatrics"
DOI: 10.1017/s1041610224002552
Abstract: Objectives: Intravenous ketamine (IVK) and intranasal esketamine (ESK) are increasingly used in treatment- resistant depression (TRD). There is limited data on head-to-head comparison as well as few reports on effects across age groups. Methods: A… read more here.
Keywords: age; response; infusion; intranasal ... See more keywords
10 Pharmacodynamics and Tolerability of Intranasally Administered Immediate-Release Amphetamine Sulfate Among Recreational Intranasal StimulantUsers
Sign Up to like & getrecommendations! Published in 2019 at "CNS Spectrums"
DOI: 10.1017/s1092852919000063
Abstract: Abstract Study Objective Despite increased nonmedical use of ADHD prescription stimulants, there are limited data to inform selection of intranasal doses for abuse-potential evaluations. This study determined a dose of amphetamine sulfate that is tolerable… read more here.
Keywords: intranasal; amphetamine sulfate; drug liking; placebo ... See more keywords
Single-dose intranasal adenovirus-based RSV vaccines targeting G and M2
Sign Up to like & getrecommendations! Published in 2025 at "NPJ Vaccines"
DOI: 10.1038/s41541-025-01186-x
Abstract: We have developed adenovector-based vaccines targeting G and M2 protein of respiratory syncytial virus. Single intranasal vaccination induced robust G protein-specific IgG and IgA responses, as well as M2-specific CD8+ T-cell immunity, and provided protection… read more here.
Keywords: single dose; adenovirus based; dose intranasal; intranasal ... See more keywords
LTA1 is a safe, intranasal enterotoxin-based adjuvant that improves vaccine protection against influenza in young, old and B-cell-depleted (μMT) mice
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-51356-w
Abstract: Enterotoxin-based adjuvants including cholera toxin and heat-labile toxin (LT) are powerful manipulators of mucosal immunity; however, past clinical trials identified unacceptable neurological toxicity when LT or mutant AB5 adjuvant proteins were added to intranasal vaccines.… read more here.
Keywords: protection; intranasal; adjuvant improves; enterotoxin ... See more keywords
A single intranasal dose of essential oil spray confers modulation of the nasopharyngeal microbiota and short-term inhibition of Mannheimia in feedlot cattle: a pilot study
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-023-50704-1
Abstract: Five essential oils (EOs) were previously characterized in vitro and identified as candidate EOs for the development of an intranasal EO spray to mitigate bovine respiratory disease (BRD) pathogens. In the present study, these EOs… read more here.
Keywords: spray; study; feedlot cattle; intranasal ... See more keywords
Intranasal Osteosarcoma in a Dog-A Case Report.
Sign Up to like & getrecommendations! Published in 2018 at "Topics in companion animal medicine"
DOI: 10.1053/j.tcam.2018.04.001
Abstract: Osteosarcoma is the most commonly reported bone tumor in dogs, typically affecting the axial and appendicular skeleton. Involvement of the paranasal sinuses and the nasal cavity is extremely rare. This report describes a 6-year-old, female,… read more here.
Keywords: intranasal; dog case; report; intranasal osteosarcoma ... See more keywords