Excretion of mephedrone and its phase I metabolites in urine after a controlled intranasal administration to healthy human volunteers
Sign Up to like & getrecommendations! Published in 2022 at "Drug Testing and Analysis"
DOI: 10.1002/dta.3214
Abstract: Abstract Mephedrone is a stimulant drug structurally related to cathinone. At present, there are no data available on the excretion profile of mephedrone and its metabolites in urine after controlled intranasal administration to human volunteers.… read more here.
Keywords: administration; mephedrone; metabolites urine; intranasal administration ... See more keywords
Effect of Intranasal Administration of Multipotent Mesenchymal Stromal Cell Exosomes on Memory of Mice in Alzheimer’s Disease Model
Sign Up to like & getrecommendations! Published in 2021 at "Bulletin of Experimental Biology and Medicine"
DOI: 10.1007/s10517-021-05109-3
Abstract: We studied the effect of intranasal administration of exosomes obtained by culturing of multipotent mesenchymal stromal cells (MMSC) isolated from the Wharton’s jelly of the human umbilical cord on spatial memory of olfactory bulbectomized mice… read more here.
Keywords: administration; alzheimer disease; effect intranasal; intranasal administration ... See more keywords
Intranasal administration of carbamazepine-loaded carboxymethyl chitosan nanoparticles for drug delivery to the brain
Sign Up to like & getrecommendations! Published in 2018 at "Asian Journal of Pharmaceutical Sciences"
DOI: 10.1016/j.ajps.2017.09.001
Abstract: Graphical Abstract CD/CS-SCU-NPs were prepared by ionic cross-linking method. Orthogonal design was used to optimize the formulation. The optimum formulation was tested in vitro and in vivo.Unlabelled image read more here.
Keywords: carboxymethyl chitosan; carbamazepine loaded; chitosan nanoparticles; loaded carboxymethyl ... See more keywords
Intranasal administration of transforming growth factor-β1 elicits rapid-acting antidepressant-like effects in a chronic social defeat stress model: A role of TrkB signaling
Sign Up to like & getrecommendations! Published in 2021 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2021.04.010
Abstract: (R,S)-ketamine causes rapid-acting and sustained antidepressant effects in treatment-resistant patients with depression although the precise molecular mechanisms underlying its antidepressant action remain unclear. We recently reported that transforming growth factor (TGF)-β1 might contribute to the… read more here.
Keywords: trkb signaling; rapid acting; like effects; intranasal administration ... See more keywords
Kaempferol‐loaded mucoadhesive nanoemulsion for intranasal administration reduces glioma growth in vitro
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Pharmaceutics"
DOI: 10.1016/j.ijpharm.2018.03.055
Abstract: &NA; In order to search for new approaches to treat glioma, intranasal administration has been proposed as an alternative route to deliver drugs into the brain. Among the drug alternatives, kaempferol (KPF) has been reported… read more here.
Keywords: intranasal administration; kpf; mucoadhesive nanoemulsion; kpf mne ... See more keywords
Nose-to-brain delivery of levetiracetam after intranasal administration to mice.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2019.04.047
Abstract: Despite being one of the most commonly prescribed antiepileptic drugs, levetiracetam is marketed in oral and intravenous dosage forms, which are associated to drug-drug interactions and drug-resistant epilepsy (DRE). The purpose of the present study… read more here.
Keywords: intranasal; levetiracetam; drug; intranasal administration ... See more keywords
Intranasal administration of small extracellular vesicles derived from mesenchymal stem cells ameliorated the experimental autoimmune encephalomyelitis.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.107207
Abstract: Experimental autoimmune encephalomyelitis (EAE) is a mouse model for the human multiple sclerosis, which is characterized by inflammation in the central nervous system (CNS), de-myelination of axonal neurons, and loss of motor coordination. The aim… read more here.
Keywords: administration; intranasal administration; msc sev; autoimmune encephalomyelitis ... See more keywords
Effect of intranasal administration of neurotrophic factors on regeneration of chemically degenerated olfactory epithelium in aging mice
Sign Up to like & getrecommendations! Published in 2018 at "Neuroreport"
DOI: 10.1097/wnr.0000000000001125
Abstract: In the mammalian olfactory epithelium (OE), neurogenesis continues throughout the lifetime, by replacing olfactory receptor neurons (ORNs) lost by normal turnover in the postnatal period. However, this ability decreases with age and/or because of various… read more here.
Keywords: administration; intranasal administration; aging mice; growth factor ... See more keywords
Pharmacokinetics and tolerability of intranasal or intravenous administration of nalbuphine in infants
Sign Up to like & getrecommendations! Published in 2022 at "Archives of Disease in Childhood"
DOI: 10.1136/archdischild-2022-323807
Abstract: Objectives Intranasal nalbuphine could be a safe, efficacious and non-invasive alternative to parenteral pain medication in infants. We aimed to assess pharmacokinetics (PK) and tolerability of intranasal and intravenous nalbuphine administration in infants. Methods Prospective… read more here.
Keywords: administration; pharmacokinetics tolerability; tolerability intranasal; intranasal intravenous ... See more keywords
Nasal administration of recombinant Neospora caninum secreting IL-15/IL-15Rα inhibits metastatic melanoma development in lung
Sign Up to like & getrecommendations! Published in 2023 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2023-006683
Abstract: Background Metastases are the leading cause of mortality in many cancer types and lungs are one of the most common sites of metastasis alongside the liver, brain, and bones. In melanoma, 85% of late-stage patients… read more here.
Keywords: administration; lung metastases; intranasal administration; caninum ... See more keywords
Non-specific protection from respiratory tract infections in cattle generated by intranasal administration of an innate immune stimulant
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0235422
Abstract: Alternatives to antibiotics for prevention of respiratory tract infections in cattle are urgently needed given the increasing public and regulatory pressure to reduce overall antibiotic usage. Activation of local innate immune defenses in the upper… read more here.
Keywords: intranasal administration; innate immune; non specific; respiratory tract ... See more keywords