Intranasal Delivery of Functionalized Polymeric Nanomaterials to the Brain (Adv. Healthcare Mater. 11/2022)
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DOI: 10.1002/adhm.202102610
Abstract: Intravenous delivery of nanomaterials containing therapeutic agents and various cargos for treating neurological disorders is often constrained by low delivery efficacy due to difficulties in passing the blood-brain barrier (BBB). Nanoparticles (NPs) administered intranasally can… read more here.
Keywords: intranasal delivery; functionalized polymeric; brain; delivery functionalized ... See more keywords
Development and optimization of chitosan coated nanoemulgel of telmisartan for intranasal delivery: A comparative study
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2021.102341
Abstract: Abstract Dementia is a degenerative brain disease, which is associated with severe cognitive impairments, where angiotensin receptor blockers (e.g., telmisartan) shown to attenuate demented conditions. The objective of this study is to formulate and characterize… read more here.
Keywords: tmneg; chitosan coated; intranasal delivery; release ... See more keywords
Intranasal delivery of a novel acetylcholinesterase inhibitor HLS‐3 for treatment of Alzheimer's disease
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DOI: 10.1016/j.lfs.2018.06.032
Abstract: Aim: The present study aims to investigate the pharmacokinetics and pharmacodynamics of HLS‐3, a tacrine dimer with high anti‐acetylcholinesterase activity for the treatment of Alzheimer's disease. Main methods: In vitro Calu‐3 and Caco‐2 cell monolayer… read more here.
Keywords: hls; alzheimer disease; treatment alzheimer; intranasal delivery ... See more keywords
Intranasal delivery of antipsychotic drugs
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DOI: 10.1016/j.schres.2016.11.027
Abstract: Antipsychotic drugs are used to treat psychotic disorders that afflict millions globally and cause tremendous emotional, economic and healthcare burdens. However, the potential of intranasal delivery to improve brain-specific targeting remains unrealized. In this article,… read more here.
Keywords: intranasal delivery; delivery; delivery antipsychotic; brain ... See more keywords
Intranasal Delivery of Antigen-Coated Polymer Particles Protects against Pseudomonas aeruginosa Infection.
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DOI: 10.1021/acsinfecdis.1c00434
Abstract: Pseudomonas aeruginosa is an opportunistic human pathogen that is intrinsically resistant to multiple antibiotics, causing severe and persistent infections in immunocompromised individuals. This bacterium has been listed as a priority pathogen by the WHO in… read more here.
Keywords: antigen coated; intranasal delivery; pseudomonas aeruginosa; aeruginosa infection ... See more keywords
The potential of intranasal delivery of nanocrystals in powder form on the improvement of zaleplon performance: in-vitro, in-vivo assessment
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DOI: 10.1080/03639045.2021.1879834
Abstract: Abstract Objective The present work focuses on improving zaleplon (ZAP) performance through nanosizing its insoluble particles which were then delivered intranasally in powder form. Significance Since nanopowders have an exceptional ability to cross cell membrane,… read more here.
Keywords: powder form; intranasal delivery; form; performance ... See more keywords
Harnessing Intranasal Delivery Systems of Sumatriptan for the Treatment of Migraine
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DOI: 10.1155/2022/3692065
Abstract: Sumatriptan (ST) is a commonly prescribed drug for treating migraine. The efficiency of several routes of ST administration has been investigated. Recently, the intranasal route with different delivery systems has gained interest owing to its… read more here.
Keywords: intranasal delivery; delivery; migraine; delivery systems ... See more keywords
Thermoreversible Carbamazepine In Situ Gel for Intranasal Delivery: Development and In Vitro, Ex Vivo Evaluation
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DOI: 10.1208/s12249-022-02439-x
Abstract: Over the past decade, intranasal (IN) delivery has been gaining attention as an alternative approach to conventional drug delivery routes targeting the brain. Carbamazepine (CBZ) is available as an orally ingestible formulation. The present study… read more here.
Keywords: intranasal delivery; gel; situ gel; release ... See more keywords
Intranasal Delivery of Gene-Edited Microglial Exosomes Improves Neurological Outcomes after Intracerebral Hemorrhage by Regulating Neuroinflammation
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DOI: 10.3390/brainsci13040639
Abstract: Neural inflammatory response is a crucial pathological change in intracerebral hemorrhage (ICH) which accelerates the formation of perihematomal edema and aggravates neural cell death. Although surgical and drug treatments for ICH have advanced rapidly in… read more here.
Keywords: microglial exosomes; intranasal delivery; neuroinflammation; brain ... See more keywords
Utilization of Polymeric Micelles as a Lucrative Platform for Efficient Brain Deposition of Olanzapine as an Antischizophrenic Drug via Intranasal Delivery
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DOI: 10.3390/ph15020249
Abstract: Schizophrenia is a mental disorder characterized by alterations in cognition, behavior and emotions. Oral olanzapine (OZ) administration is extensively metabolized (~up to 40% of the administrated dose). In addition, OZ is a P-glycoproteins substrate that… read more here.
Keywords: administration; intranasal delivery; polymeric micelles; brain ... See more keywords
Design and Development of Levodopa Loaded Polymeric Nanoparticles for Intranasal Delivery
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DOI: 10.3390/ph15030370
Abstract: Intranasal delivery is an alternative administration route to deliver levodopa (L-Dopa) to the brain. This drug delivery route offers high drug permeability across the nasal epithelium and rapid absorption into the central nervous system (CNS)… read more here.
Keywords: nanoparticles intranasal; intranasal delivery; microscopy; chitosan nanoparticles ... See more keywords