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Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202102610
Abstract: Intravenous delivery of nanomaterials containing therapeutic agents and various cargos for treating neurological disorders is often constrained by low delivery efficacy due to difficulties in passing the blood-brain barrier (BBB). Nanoparticles (NPs) administered intranasally can…
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Keywords:
intranasal delivery;
functionalized polymeric;
brain;
delivery functionalized ... See more keywords
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Published in 2021 at "Journal of Drug Delivery Science and Technology"
DOI: 10.1016/j.jddst.2021.102341
Abstract: Abstract Dementia is a degenerative brain disease, which is associated with severe cognitive impairments, where angiotensin receptor blockers (e.g., telmisartan) shown to attenuate demented conditions. The objective of this study is to formulate and characterize…
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Keywords:
tmneg;
chitosan coated;
intranasal delivery;
release ... See more keywords
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Published in 2018 at "Life Sciences"
DOI: 10.1016/j.lfs.2018.06.032
Abstract: Aim: The present study aims to investigate the pharmacokinetics and pharmacodynamics of HLS‐3, a tacrine dimer with high anti‐acetylcholinesterase activity for the treatment of Alzheimer's disease. Main methods: In vitro Calu‐3 and Caco‐2 cell monolayer…
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Keywords:
hls;
alzheimer disease;
treatment alzheimer;
intranasal delivery ... See more keywords
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Published in 2017 at "Schizophrenia Research"
DOI: 10.1016/j.schres.2016.11.027
Abstract: Antipsychotic drugs are used to treat psychotic disorders that afflict millions globally and cause tremendous emotional, economic and healthcare burdens. However, the potential of intranasal delivery to improve brain-specific targeting remains unrealized. In this article,…
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Keywords:
intranasal delivery;
delivery;
delivery antipsychotic;
brain ... See more keywords
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Published in 2022 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.1c00434
Abstract: Pseudomonas aeruginosa is an opportunistic human pathogen that is intrinsically resistant to multiple antibiotics, causing severe and persistent infections in immunocompromised individuals. This bacterium has been listed as a priority pathogen by the WHO in…
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Keywords:
antigen coated;
intranasal delivery;
pseudomonas aeruginosa;
aeruginosa infection ... See more keywords
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Published in 2021 at "Drug Development and Industrial Pharmacy"
DOI: 10.1080/03639045.2021.1879834
Abstract: Abstract Objective The present work focuses on improving zaleplon (ZAP) performance through nanosizing its insoluble particles which were then delivered intranasally in powder form. Significance Since nanopowders have an exceptional ability to cross cell membrane,…
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Keywords:
powder form;
intranasal delivery;
form;
performance ... See more keywords
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Published in 2022 at "BioMed Research International"
DOI: 10.1155/2022/3692065
Abstract: Sumatriptan (ST) is a commonly prescribed drug for treating migraine. The efficiency of several routes of ST administration has been investigated. Recently, the intranasal route with different delivery systems has gained interest owing to its…
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Keywords:
intranasal delivery;
delivery;
migraine;
delivery systems ... See more keywords
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Published in 2022 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-022-02439-x
Abstract: Over the past decade, intranasal (IN) delivery has been gaining attention as an alternative approach to conventional drug delivery routes targeting the brain. Carbamazepine (CBZ) is available as an orally ingestible formulation. The present study…
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Keywords:
intranasal delivery;
gel;
situ gel;
release ... See more keywords
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Published in 2023 at "Brain Sciences"
DOI: 10.3390/brainsci13040639
Abstract: Neural inflammatory response is a crucial pathological change in intracerebral hemorrhage (ICH) which accelerates the formation of perihematomal edema and aggravates neural cell death. Although surgical and drug treatments for ICH have advanced rapidly in…
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Keywords:
microglial exosomes;
intranasal delivery;
neuroinflammation;
brain ... See more keywords
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Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15020249
Abstract: Schizophrenia is a mental disorder characterized by alterations in cognition, behavior and emotions. Oral olanzapine (OZ) administration is extensively metabolized (~up to 40% of the administrated dose). In addition, OZ is a P-glycoproteins substrate that…
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Keywords:
administration;
intranasal delivery;
polymeric micelles;
brain ... See more keywords
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Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15030370
Abstract: Intranasal delivery is an alternative administration route to deliver levodopa (L-Dopa) to the brain. This drug delivery route offers high drug permeability across the nasal epithelium and rapid absorption into the central nervous system (CNS)…
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Keywords:
nanoparticles intranasal;
intranasal delivery;
microscopy;
chitosan nanoparticles ... See more keywords