In vitro study of the mechanism of intraneuronal β-amyloid aggregation in Alzheimer's disease.
Sign Up to like & getrecommendations! Published in 2020 at "Archives of physiology and biochemistry"
DOI: 10.1080/13813455.2020.1722707
Abstract: Alzheimer's disease (AD) is atrophy of brain cells that lead to decline in the mental capacity and memory. This study investigated the mechanism which postulates that intraneuronal accumulation of amyloid aggregates for pathogenesis of AD.… read more here.
Keywords: aggregation; intraneuronal amyloid; alzheimer disease; disease ... See more keywords
Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Neurodegeneration"
DOI: 10.1186/s13024-018-0244-x
Abstract: BackgroundBesides the two main classical features of amyloid beta aggregation and tau-containing neurofibrillary tangle deposition, neuroinflammation plays an important yet unclear role in the pathophysiology of Alzheimer’s disease (AD). Microglia are believed to be key… read more here.
Keywords: intraneuronal amyloid; csf1r; neuritic plaque; deposition ... See more keywords
Intraneuronal β-Amyloid Accumulation: Aging HIV-1 Human and HIV-1 Transgenic Rat Brain
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14061268
Abstract: The prevalence of HIV-1 associated neurocognitive disorders (HAND) is significantly greater in older, relative to younger, HIV-1 seropositive individuals; the neural pathogenesis of HAND in older HIV-1 seropositive individuals, however, remains elusive. To address this… read more here.
Keywords: amyloid accumulation; hiv; rat; intraneuronal amyloid ... See more keywords