Everolimus depletes plaque macrophages, abolishes intraplaque neovascularization and improves survival in mice with advanced atherosclerosis.
Sign Up to like & getrecommendations! Published in 2019 at "Vascular pharmacology"
DOI: 10.1016/j.vph.2018.12.004
Abstract: BACKGROUND AND AIMS Inhibition of the mechanistic target of rapamycin (mTOR) is a promising approach to halt atherogenesis in different animal models. This study evaluated whether the mTOR inhibitor everolimus can stabilize pre-existing plaques, prevent… read more here.
Keywords: advanced atherosclerosis; intraplaque neovascularization; everolimus; plaque macrophages ... See more keywords
Long-Term Clinical Effects of Carotid Intraplaque Neovascularization in Patients with Coronary Artery Disease
Sign Up to like & getrecommendations! Published in 2020 at "Korean Journal of Radiology"
DOI: 10.3348/kjr.2019.0550
Abstract: Objective To investigate the predictive value of intraplaque neovascularization (IPN) for cardiovascular outcomes. Materials and Methods We evaluated 217 patients with coronary artery disease (CAD) (158 men; mean age, 68 ± 10 years) with a… read more here.
Keywords: patients coronary; coronary artery; intraplaque neovascularization; ipn ... See more keywords