Analysis of genomic and immune intratumor heterogeneity in linitis plastica via multiregional exome and T-cell-receptor sequencing.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular oncology"
DOI: 10.1002/1878-0261.13381
Abstract: The molecular landscape and the intratumor heterogeneity (ITH) architecture of gastric linitis plastica (LP) are poorly understood. We performed whole-exome sequencing (WES) and T-cell receptor (TCR) sequencing on 40 tumor regions from four LP patients.… read more here.
Keywords: cell receptor; cell; intratumor heterogeneity; linitis plastica ... See more keywords
Aneuploidy, TP53 mutation, and amplification of MYC correlate with increased intratumor heterogeneity and poor prognosis of breast cancer patients
Sign Up to like & getrecommendations! Published in 2018 at "Genes"
DOI: 10.1002/gcc.22515
Abstract: The clinical course of breast cancer varies from one patient to another. Currently, the choice of therapy relies on clinical parameters and histological and molecular tumor features. Alas, these markers are informative in only a… read more here.
Keywords: cancer; aneuploid tumors; intratumor heterogeneity; breast cancer ... See more keywords
Multisite tumor sampling enhances the detection of intratumor heterogeneity at all different temporal stages of tumor evolution
Sign Up to like & getrecommendations! Published in 2017 at "Virchows Archiv"
DOI: 10.1007/s00428-017-2223-y
Abstract: Intratumor heterogeneity (ITH) is an inherent process of tumor development that has received much attention in previous years, as it has become a major obstacle for the success of targeted therapies. ITH is also temporally… read more here.
Keywords: tumor sampling; intratumor heterogeneity; multisite tumor; tumor evolution ... See more keywords
A large-scale snapshot of intratumor heterogeneity in human cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer cell"
DOI: 10.1016/j.ccell.2021.03.005
Abstract: Using sophisticated statistical analyses on population-scale cancer whole-genome sequences, a new study published in Cell characterizes the genomic architecture of intratumor heterogeneity (ITH). It results in an unprecedented snapshot of subclones in about 30 cancer… read more here.
Keywords: cancer; large scale; scale snapshot; intratumor heterogeneity ... See more keywords
Intratumor heterogeneity is biomarker specific and challenges the association with heterogeneity in multimodal functional imaging in head and neck squamous cell carcinoma.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of radiology"
DOI: 10.1016/j.ejrad.2021.109668
Abstract: RATIONALE Tumor biopsy cannot detect heterogeneity and an association between heterogeneity in functional imaging and molecular biology will have an impact on both diagnostics and treatment possibilities. PURPOSE Multiparametric imaging can provide 3D information on… read more here.
Keywords: heterogeneity; functional imaging; intratumor heterogeneity; tumor ... See more keywords
Dissecting Intratumor Heterogeneity in HCC: New Research Strategies & Clinical Implications.
Sign Up to like & getrecommendations! Published in 2022 at "Carcinogenesis"
DOI: 10.1093/carcin/bgac099
Abstract: Hepatocellular carcinoma (HCC) accounts for the majority of liver cancers and is driven by a multitude of viral, metabolic, and lifestyle factors initiating liver injury that subsequently progresses to cancer. Despite significant medical advancements, current… read more here.
Keywords: dissecting intratumor; heterogeneity; clinical implications; intratumor heterogeneity ... See more keywords
Understanding intratumor heterogeneity by combining genome analysis and mathematical modeling
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Science"
DOI: 10.1111/cas.13510
Abstract: Cancer is composed of multiple cell populations with different genomes. This phenomenon called intratumor heterogeneity (ITH) is supposed to be a fundamental cause of therapeutic failure. Therefore, its principle‐level understanding is a clinically important issue.… read more here.
Keywords: intratumor heterogeneity; mathematical modeling; genome analysis; analysis mathematical ... See more keywords
Intratumor Heterogeneity and Antitumor Immunity Shape One Another Bidirectionally
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-21-1355
Abstract: Abstract Over the last decade, it has become clear that the genomic landscapes of tumors profoundly impact their immunogenicity and how tumor cells interact with immune cells. Whereas past discoveries mainly focused on the interplay… read more here.
Keywords: response; antitumor; intratumor heterogeneity; immunity ... See more keywords
Abstract 5924: Intratumor heterogeneity in thyroid cancer progression
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5924
Abstract: Thyroid cancer (CT) is the most common endocrine organs malignancy and is classified into:well-differentiated carcinomas, characterized by favourable prognosis and sensitive to standardtreatments, and undifferentiated carcinomas (UTC), the most lethal and highly refractoryagainst current therapies.… read more here.
Keywords: technology; progression; intratumor heterogeneity; thyroid cancer ... See more keywords
New insights from the widening homogeneity perspective to target intratumor heterogeneity
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Communications"
DOI: 10.1186/s40880-018-0287-y
Abstract: Precision medicine has shed new light on the treatment of heterogeneous cancer patients. However, intratumor heterogeneity strongly constrains the clinical benefit of precision medicine. Thus, rethinking therapeutic strategies from a different facet within the precision… read more here.
Keywords: target intratumor; medicine; precision medicine; intratumor heterogeneity ... See more keywords
SpliceHetero: An information theoretic approach for measuring spliceomic intratumor heterogeneity from bulk tumor RNA-seq
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0223520
Abstract: Motivation Intratumor heterogeneity (ITH) represents the diversity of cell populations that make up cancer tissue. The level of ITH in a tumor is usually measured by a genomic variation profile, such as copy number variation… read more here.
Keywords: heterogeneity; intratumor heterogeneity; measuring spliceomic; cancer ... See more keywords