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Intratumoral CD40 activation and checkpoint blockade induces T cell-mediated eradication of melanoma in the brain

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0 Published in 2017 at "Nature Communications"

DOI: 10.1038/s41467-017-01572-7

Abstract: CD40 agonists bind the CD40 molecule on antigen-presenting cells and activate them to prime tumor-specific CD8+ T cell responses. Here, we study the antitumor activity and mechanism of action of a nonreplicating adenovirus encoding a… read more here.

Keywords: eradication; melanoma; checkpoint blockade; cd40 ... See more keywords