Intratumoral Delivery of Interferonγ‐Secreting Mesenchymal Stromal Cells Repolarizes Tumor‐Associated Macrophages and Suppresses Neuroblastoma Proliferation In Vivo
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DOI: 10.1002/stem.2801
Abstract: Neuroblastoma, the most common extracranial solid tumor in childhood, remains a therapeutic challenge. However, one promising patient treatment strategy is the delivery of anti‐tumor therapeutic agents via mesenchymal stromal cell (MSC) therapy. MSCs have been… read more here.
Keywords: intratumoral delivery; mesenchymal stromal; interferon; proliferation ... See more keywords
Intratumoral Delivery of Plasmid IL12 Via Electroporation Leads to Regression of Injected and Noninjected Tumors in Merkel Cell Carcinoma
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DOI: 10.1158/1078-0432.ccr-19-0972
Abstract: Purpose: IL12 promotes adaptive type I immunity and has demonstrated antitumor efficacy, but systemic administration leads to severe adverse events (AE), including death. This pilot trial investigated safety, efficacy, and immunologic activity of intratumoral delivery… read more here.
Keywords: merkel cell; cell carcinoma; intratumoral delivery; il12 ... See more keywords
Intratumoral Delivery of STING Agonist Results in Clinical Responses in Canine Glioblastoma
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DOI: 10.1158/1078-0432.ccr-21-1914
Abstract: Purpose: Activation of STING (stimulator of interferon genes) can trigger a robust, innate antitumor immune response in immunologically “cold” tumors such as glioblastoma. Patients and Methods: A small-molecule STING agonist, IACS-8779, was stereotactically administered using… read more here.
Keywords: results clinical; sting agonist; intratumoral delivery; delivery sting ... See more keywords
Intratumoral Delivery of Doxorubicin on Folate-Conjugated Graphene Oxide by In-Situ Forming Thermo-Sensitive Hydrogel for Breast Cancer Therapy
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DOI: 10.3390/nano7110388
Abstract: By taking advantage of the pH-sensitive drug release property of graphene oxide (GO) after intracellular uptake, we prepared folic acid (FA)-conjugated GO (GOFA) for targeted delivery of the chemotherapeutic drug doxorubicin (DOX). GOFA-DOX was further… read more here.
Keywords: intratumoral delivery; gofa dox; dox; hacpn ... See more keywords