Intratumoral genetic heterogeneity and number of cytogenetic aberrations provide additional prognostic significance in chronic lymphocytic leukemia
Sign Up to like & getrecommendations! Published in 2017 at "Genetics in Medicine"
DOI: 10.1038/gim.2016.81
Abstract: Purpose:Chronic lymphocytic leukemia (CLL) is a heterogeneous disease with cytogenetic aberrations that are still considered the gold standard of prognostic factors. However, heterogeneity remains within each cytogenetic group, especially in patients with concomitant cytogenetic aberrations.Methods:A… read more here.
Keywords: cytogenetic aberrations; number cytogenetic; intratumoral genetic; heterogeneity ... See more keywords
Intratumoral Genetic and Functional Heterogeneity in Pediatric Glioblastoma.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer research"
DOI: 10.1158/0008-5472.can-18-3441
Abstract: Pediatric glioblastoma (pGBM) is a lethal cancer with no effective therapies. To understand the mechanisms of tumor evolution in this cancer, we performed whole-genome sequencing with linked reads on longitudinally resected pGBM samples. Our analyses… read more here.
Keywords: slow cycling; glioblastoma; pediatric glioblastoma; cancer ... See more keywords