Intratumoral heterogeneity, treatment response, and survival outcome of ER‐positive HER2‐positive breast cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Medicine"
DOI: 10.1002/cam4.5788
Abstract: ER+HER2+ breast cancer requires most types of systemic therapies perioperatively. However, treatment resistance is often experienced. The current study investigated the predictive and prognostic value of intratumoral heterogeneity and conventional clinicopathological factors in patients with… read more here.
Keywords: her2; breast cancer; treatment; cancer ... See more keywords
Circumventing intratumoral heterogeneity to identify potential therapeutic targets in hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of hepatology"
DOI: 10.1016/j.jhep.2017.03.005
Abstract: BACKGROUND & AIMS Identifying target genetic mutations in hepatocellular carcinoma (HCC) for therapy is made challenging by intratumoral heterogeneity. Circulating cell-free DNAs (cfDNA) may contain a more complete mutational spectrum compared to a single tumor… read more here.
Keywords: single tumor; hepatocellular carcinoma; heterogeneity; intratumoral heterogeneity ... See more keywords
Intratumoral heterogeneity of copy number variation in lung cancer harboring L858R via immunohistochemical heterogeneous staining.
Sign Up to like & getrecommendations! Published in 2018 at "Lung cancer"
DOI: 10.1016/j.lungcan.2018.08.013
Abstract: BACKGROUND Although intratumoral heterogeneity is commonly observed in several cancers, few studies have shown its presence in EGFR-mutated lung cancer. We performed immunohistochemistry to analyze the intratumoral heterogeneity in EGFR-mutated (L858R) lung cancer and performed… read more here.
Keywords: intratumoral heterogeneity; copy number; part;
High-content, cell-by-cell assessment of HER2 overexpression and amplification: a tool for intratumoral heterogeneity detection in breast cancer
Sign Up to like & getrecommendations! Published in 2019 at "Laboratory Investigation"
DOI: 10.1038/s41374-018-0172-y
Abstract: Immunohistochemistry and fluorescence in situ hybridization are the two standard methods for human epidermal growth factor receptor 2 (HER2) assessment. However, they have severe limitations to assess quantitatively intratumoral heterogeneity (ITH) when multiple subclones of… read more here.
Keywords: high content; heterogeneity; breast cancer; intratumoral heterogeneity ... See more keywords
Use of inkjet-printed single cells to quantify intratumoral heterogeneity.
Sign Up to like & getrecommendations! Published in 2020 at "Biofabrication"
DOI: 10.1088/1758-5090/ab9491
Abstract: Quantification of intratumoural heterogeneity is essential for designing effective therapeutic strategies in the age of personalized medicine. In this study, we used a piezoelectric inkjet printer to enable analysis of intratumoral heterogeneity in a bladder… read more here.
Keywords: inkjet printed; heterogeneity; tumor organoids; intratumoral heterogeneity ... See more keywords
Intratumoral heterogeneity: pathways to treatment resistance and relapse in human glioblastoma
Sign Up to like & getrecommendations! Published in 2017 at "Annals of Oncology"
DOI: 10.1093/annonc/mdx169
Abstract: Intratumoral heterogeneity (ITH) has increasingly being described for multiple cancers as the root cause of therapy resistance. Recent studies have started to explore the scope of ITH in glioblastoma (GBM), a highly aggressive and fatal… read more here.
Keywords: glioblastoma; treatment; intratumoral heterogeneity; resistance ... See more keywords
CBIO-09. INTRATUMORAL HETEROGENEITY OF DIELECTRIC PROPERTIES IN GLIOBLASTOMA
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-oncology"
DOI: 10.1093/neuonc/noaa215.069
Abstract: Recently, tumor treating fields (TTFields) were established for the treatment of newly diagnosed glioblastoma (GBM). One of the most crucial parameters defining the treatment efficacy of TTFields is the electric field intensity, which depends on… read more here.
Keywords: dielectric properties; tissue; intratumoral heterogeneity; conductivity ... See more keywords
Intratumoral heterogeneity of MYC drives medulloblastoma metastasis and angiogenesis.
Sign Up to like & getrecommendations! Published in 2022 at "Neuro-oncology"
DOI: 10.1093/neuonc/noac068
Abstract: BACKGROUND Intratumoral heterogeneity is crucially involved in metastasis, resistance to therapy and cancer relapse. Amplifications of the proto-oncogene MYC display notable heterogeneity at the single-cell level and are associated with a particularly dismal prognosis in… read more here.
Keywords: metastasis; heterogeneity; cell; myc driven ... See more keywords
Spatially coherent modeling of 3D FDG-PET data for assessment of intratumoral heterogeneity and uptake gradients
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Imaging"
DOI: 10.1117/1.jmi.9.4.045003
Abstract: Abstract. Purpose: Radiomics have become invaluable for non-invasive cancer patient risk prediction, and the community now turns to exogenous assessment, e.g., from genomics, for interpretability of these agnostic analyses. Yet, some opportunities for clinically interpretable… read more here.
Keywords: heterogeneity; spatially coherent; uptake gradients; coherent modeling ... See more keywords
Single-Cell Transcriptome Profiling Reveals Intratumoral Heterogeneity and Molecular Features of Ductal Carcinoma In Situ.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer research"
DOI: 10.1158/0008-5472.can-22-0090
Abstract: Ductal carcinoma in situ (DCIS) is a precursor to invasive breast cancer. The frequency of DCIS is increasing because of routine mammography; however, the biological features and intratumoral heterogeneity of DCIS remain obscure. To address… read more here.
Keywords: ductal carcinoma; heterogeneity; cell; dcis ... See more keywords
Abstract 4700: Quantification of intratumoral heterogeneity in individual luminal A breast cancers from whole transcriptome data through semi-supervised learning
Sign Up to like & getrecommendations! Published in 2019 at "Tumor Biology"
DOI: 10.1158/1538-7445.am2019-4700
Abstract: Introduction PAM50 gene profiling assigns individual breast cancers (BCas) to one of five intrinsic subtypes. However, individual tumors vary in their adherence to the assigned subtype, and a subset of these may show admixture with… read more here.
Keywords: intratumoral heterogeneity; whole transcriptome; luma cases; breast cancers ... See more keywords