Intratumoral heterogeneity, treatment response, and survival outcome of ER‐positive HER2‐positive breast cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Medicine"
DOI: 10.1002/cam4.5788
Abstract: ER+HER2+ breast cancer requires most types of systemic therapies perioperatively. However, treatment resistance is often experienced. The current study investigated the predictive and prognostic value of intratumoral heterogeneity and conventional clinicopathological factors in patients with… read more here.
Keywords: her2; breast cancer; treatment; cancer ... See more keywords
Intratumoral heterogeneity of cancer driver genomic alterations in myxoid liposarcomas
Sign Up to like & getrecommendations! Published in 2025 at "Cancer"
DOI: 10.1002/cncr.35937
Abstract: Myxoid liposarcomas (MLS) are rare malignant mesenchymal tumors characterized by specific translocations t(12;16) and t(12;22) with limited additional driver mutations, most notably in PIK3CA and the TERT promoter. PIK3CA is considered a promising therapeutic target.… read more here.
Keywords: driver; heterogeneity cancer; myxoid liposarcomas; intratumoral heterogeneity ... See more keywords
Circumventing intratumoral heterogeneity to identify potential therapeutic targets in hepatocellular carcinoma.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of hepatology"
DOI: 10.1016/j.jhep.2017.03.005
Abstract: BACKGROUND & AIMS Identifying target genetic mutations in hepatocellular carcinoma (HCC) for therapy is made challenging by intratumoral heterogeneity. Circulating cell-free DNAs (cfDNA) may contain a more complete mutational spectrum compared to a single tumor… read more here.
Keywords: single tumor; hepatocellular carcinoma; heterogeneity; intratumoral heterogeneity ... See more keywords
Intratumoral heterogeneity of copy number variation in lung cancer harboring L858R via immunohistochemical heterogeneous staining.
Sign Up to like & getrecommendations! Published in 2018 at "Lung cancer"
DOI: 10.1016/j.lungcan.2018.08.013
Abstract: BACKGROUND Although intratumoral heterogeneity is commonly observed in several cancers, few studies have shown its presence in EGFR-mutated lung cancer. We performed immunohistochemistry to analyze the intratumoral heterogeneity in EGFR-mutated (L858R) lung cancer and performed… read more here.
Keywords: intratumoral heterogeneity; copy number; part;
High-content, cell-by-cell assessment of HER2 overexpression and amplification: a tool for intratumoral heterogeneity detection in breast cancer
Sign Up to like & getrecommendations! Published in 2019 at "Laboratory Investigation"
DOI: 10.1038/s41374-018-0172-y
Abstract: Immunohistochemistry and fluorescence in situ hybridization are the two standard methods for human epidermal growth factor receptor 2 (HER2) assessment. However, they have severe limitations to assess quantitatively intratumoral heterogeneity (ITH) when multiple subclones of… read more here.
Keywords: high content; heterogeneity; breast cancer; intratumoral heterogeneity ... See more keywords
An optimized tissue sampling scheme guided by MRI features reveals intratumoral heterogeneity in glioblastoma
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-17539-4
Abstract: Glioblastoma (GBM) displays marked intratumoral heterogeneity and high invasiveness, making en bloc resection difficult. In particular, total/subtotal resection is challenging for lesions near the diencephalon, midbrain, or brainstem or in motor areas, as damage to… read more here.
Keywords: sampling scheme; tissue sampling; glioblastoma; intratumoral heterogeneity ... See more keywords
Use of inkjet-printed single cells to quantify intratumoral heterogeneity.
Sign Up to like & getrecommendations! Published in 2020 at "Biofabrication"
DOI: 10.1088/1758-5090/ab9491
Abstract: Quantification of intratumoural heterogeneity is essential for designing effective therapeutic strategies in the age of personalized medicine. In this study, we used a piezoelectric inkjet printer to enable analysis of intratumoral heterogeneity in a bladder… read more here.
Keywords: inkjet printed; heterogeneity; tumor organoids; intratumoral heterogeneity ... See more keywords
Intratumoral heterogeneity: pathways to treatment resistance and relapse in human glioblastoma
Sign Up to like & getrecommendations! Published in 2017 at "Annals of Oncology"
DOI: 10.1093/annonc/mdx169
Abstract: Intratumoral heterogeneity (ITH) has increasingly being described for multiple cancers as the root cause of therapy resistance. Recent studies have started to explore the scope of ITH in glioblastoma (GBM), a highly aggressive and fatal… read more here.
Keywords: glioblastoma; treatment; intratumoral heterogeneity; resistance ... See more keywords
CBIO-09. INTRATUMORAL HETEROGENEITY OF DIELECTRIC PROPERTIES IN GLIOBLASTOMA
Sign Up to like & getrecommendations! Published in 2020 at "Neuro-oncology"
DOI: 10.1093/neuonc/noaa215.069
Abstract: Recently, tumor treating fields (TTFields) were established for the treatment of newly diagnosed glioblastoma (GBM). One of the most crucial parameters defining the treatment efficacy of TTFields is the electric field intensity, which depends on… read more here.
Keywords: dielectric properties; tissue; intratumoral heterogeneity; conductivity ... See more keywords
Intratumoral heterogeneity of MYC drives medulloblastoma metastasis and angiogenesis.
Sign Up to like & getrecommendations! Published in 2022 at "Neuro-oncology"
DOI: 10.1093/neuonc/noac068
Abstract: BACKGROUND Intratumoral heterogeneity is crucially involved in metastasis, resistance to therapy and cancer relapse. Amplifications of the proto-oncogene MYC display notable heterogeneity at the single-cell level and are associated with a particularly dismal prognosis in… read more here.
Keywords: metastasis; heterogeneity; cell; myc driven ... See more keywords
Molecular classification and intratumoral heterogeneity of gastric adenocarcinoma
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DOI: 10.1111/pin.13427
Abstract: Gastric cancers frequently harbor striking histological complexity and diversity between lesions as well as within single lesions, known as inter‐ and intratumoral heterogeneity, respectively. The latest World Health Organization Classification of Tumors designated more than… read more here.
Keywords: classification; gastric adenocarcinoma; molecular profiles; intratumoral heterogeneity ... See more keywords