Assessing the Risk of Nephrotoxicity Associated With Non-renally Adjusted Intravenous Polymyxin B Compared with Traditional Dosing
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DOI: 10.1093/ofid/ofx163.691
Abstract: Abstract Background Prior data states that polymyxin B is renally cleared and thus required renal adjustments, however newer data suggests that polymyxin B undergoes non-renal clearance. With more aggressive dosing, potential for increased nephrotoxicity is… read more here.
Keywords: intravenous polymyxin; renally adjusted; non adjusted; polymyxin ... See more keywords
Pharmacokinetics of Polymyxin B in Hospitalized Adults with Cystic Fibrosis
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DOI: 10.1128/aac.00792-21
Abstract: The optimal polymyxin B dosage needed to achieve an efficacy target of 50 to 100 mg · h/liter when treating multidrug-resistant bacterial infections in adult cystic fibrosis (CF) patients is unclear. The pharmacokinetics of intravenous polymyxin… read more here.
Keywords: cystic fibrosis; polymyxin; intravenous polymyxin; polymyxin hospitalized ... See more keywords
Risk Factors for Acute Kidney Injury Induced by Intravenous Polymyxin B in Chinese Patients with Severe Infection
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DOI: 10.2147/idr.s363944
Abstract: Purpose To analyze the risk factors for acute kidney injury (AKI) induced by intravenous polymyxin B in Chinese patients with severe infection and to provide a reference for clinicians and pharmacists. Methods We retrospectively analyzed… read more here.
Keywords: intravenous polymyxin; infection; induced intravenous; risk factors ... See more keywords
Effectiveness and Nephrotoxicity of Intravenous Polymyxin B in Carbapenem-Resistant Gram-Negative Bacterial Infections Among Chinese Children
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DOI: 10.3389/fphar.2022.902054
Abstract: Background: No clinical study on the use of polymyxin B in Chinese children has been reported, thus making it difficult for pediatric clinicians to rationally select these drugs. Methods: A retrospective analysis of children treated… read more here.
Keywords: carbapenem resistant; intravenous polymyxin; chinese children; resistant gram ... See more keywords