MYC‐driven malignant transformation of mature murine B cells requires inhibition of both intrinsic apoptosis and p53 activity
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Immunology"
DOI: 10.1002/eji.201847585
Abstract: Increased expression of the oncogene MYC is a common feature of many B‐cell malignancies, however MYC overexpression by itself is not sufficient for transformation, and additional genetic events are required, although the exact nature of… read more here.
Keywords: malignant transformation; murine cells; transformation; expression ... See more keywords
Zinc-pretreatment triggers glutathione and Nrf2-mediated protection against inorganic mercury-induced cytotoxicity and intrinsic apoptosis in PC12 cells.
Sign Up to like & getrecommendations! Published in 2020 at "Ecotoxicology and environmental safety"
DOI: 10.1016/j.ecoenv.2020.111320
Abstract: Mercury (Hg) is a hazardous metal, poses environmental problems with severe human health effects; whereas zinc (Zn) is an essential micronutrient with antioxidant properties. The purpose of this research was to investigate the effect of… read more here.
Keywords: cell; pc12 cells; apoptosis; induced cytotoxicity ... See more keywords
Targeting the Intrinsic Apoptosis Pathway: A Window of Opportunity for Prostate Cancer
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers14010051
Abstract: Simple Summary Prostate cancer treatment has improved over the last 20 years; despite this, approximately 33,000 men died from the disease in the United States in 2020. In view of this, new treatment options are… read more here.
Keywords: cancer; apoptosis; intrinsic apoptosis; apoptosis pathway ... See more keywords
Metazoans and Intrinsic Apoptosis: An Evolutionary Analysis of the Bcl-2 Family
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23073691
Abstract: The B-cell lymphoma-2 (Bcl-2) family is a group of genes regulating intrinsic apoptosis, a process controlling events such as development, homeostasis and the innate and adaptive immune responses in metazoans. In higher organisms, Bcl-2 proteins… read more here.
Keywords: bcl family; intrinsic apoptosis; bcl proteins; family ... See more keywords
Selective Induction of Intrinsic Apoptosis in Retinoblastoma Cells by Novel Cationic Antimicrobial Dodecapeptides
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14112507
Abstract: Host defense peptides represent an important component of innate immunity. In this work, we report the anticancer properties of a panel of hyper-charged wholly cationic antimicrobial dodecapeptides (CAPs) containing multiple canonical forms of lysine and… read more here.
Keywords: intrinsic apoptosis; cationic antimicrobial; hc3 hc5; retinoblastoma ... See more keywords
Propofol induces ROS-mediated intrinsic apoptosis and migration in triple-negative breast cancer cells
Sign Up to like & getrecommendations! Published in 2020 at "Oncology Letters"
DOI: 10.3892/ol.2020.11608
Abstract: Propofol is widely applied in general anesthesia owing to its short effect and rapid recovery. Apart from its anesthetic advantages, propofol has also been observed to inhibit the growth of several types of cancer cells.… read more here.
Keywords: apoptosis; cancer cells; breast cancer; migration ... See more keywords