Rapid prediction and analysis of protein intrinsic disorder
Sign Up to like & getrecommendations! Published in 2022 at "Protein Science"
DOI: 10.1002/pro.4496
Abstract: Protein intrinsic disorder is found in all kingdoms of life and is known to underpin numerous physiological and pathological processes. Computational methods play an important role in characterizing and identifying intrinsically disordered proteins and protein… read more here.
Keywords: ridao; protein intrinsic; intrinsic disorder; analysis ... See more keywords
Exploring Protein Intrinsic Disorder with MobiDB.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0524-0_6
Abstract: Nowadays, it is well established that many proteins or regions under physiological conditions lack a fixed three-dimensional structure and are intrinsically disordered. MobiDB is the main repository of protein disorder and mobility annotations, combining different… read more here.
Keywords: exploring protein; intrinsic disorder; disorder; disorder mobidb ... See more keywords
Evolutionary Forces and Codon Bias in Different Flavors of Intrinsic Disorder in the Human Proteome
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Evolution"
DOI: 10.1007/s00239-019-09921-4
Abstract: In this study, we perform a systematic analysis of evolutionary forces (i.e., mutational bias and natural selection) that shape the codon usage bias of human genes encoding proteins characterized by different flavors of intrinsic disorder.… read more here.
Keywords: flavors intrinsic; intrinsic disorder; disorder; different flavors ... See more keywords
Role of intrinsic disorder in muscle sarcomeres.
Sign Up to like & getrecommendations! Published in 2019 at "Progress in molecular biology and translational science"
DOI: 10.1016/bs.pmbts.2019.03.014
Abstract: The role and utility of intrinsically disordered regions (IDRs) is reviewed for two groups of sarcomeric proteins, such as members of tropomodulin/leiomodin (Tmod/Lmod) protein homology group and myosin binding protein C (MyBP-C). These two types… read more here.
Keywords: intrinsic disorder; disorder muscle; role; muscle sarcomeres ... See more keywords
Intrinsically disordered proteins: Chronology of a discovery.
Sign Up to like & getrecommendations! Published in 2021 at "Biophysical chemistry"
DOI: 10.1016/j.bpc.2021.106694
Abstract: Intrinsic disorder is a new reality that appears to penetrate every corner of modern protein science. It is difficult to imagine that only 20 years ago the situation was completely different, and almost nobody had heard… read more here.
Keywords: protein; proteins chronology; intrinsic disorder; discovery ... See more keywords
Intrinsic disorder in proteins: Relevance to protein assemblies, drug design and host-pathogen interactions.
Sign Up to like & getrecommendations! Published in 2020 at "Progress in biophysics and molecular biology"
DOI: 10.1016/j.pbiomolbio.2020.06.004
Abstract: Intrinsic disorder in proteins resulting in considerable variation in structure can lead to multiple functions including multi-specificity and diverse pathologies. Protein interfaces can involve disordered regions that assemble through a concerted-fold-and-bind mechanism. The binding involves… read more here.
Keywords: intrinsic disorder; disorder; drug design; host pathogen ... See more keywords
Myofilament-associated proteins with intrinsic disorder (MAPIDs) and their resolution by computational modeling
Sign Up to like & getrecommendations! Published in 2023 at "Quarterly Reviews of Biophysics"
DOI: 10.1017/s003358352300001x
Abstract: Abstract The cardiac sarcomere is a cellular structure in the heart that enables muscle cells to contract. Dozens of proteins belong to the cardiac sarcomere, which work in tandem to generate force and adapt to… read more here.
Keywords: proteins intrinsic; biophysics; intrinsic disorder; myofilament associated ... See more keywords
flDPnn: Accurate intrinsic disorder prediction with putative propensities of disorder functions
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-24773-7
Abstract: Identification of intrinsic disorder in proteins relies in large part on computational predictors, which demands that their accuracy should be high. Since intrinsic disorder carries out a broad range of cellular functions, it is desirable… read more here.
Keywords: disorder functions; intrinsic disorder; disorder; disorder prediction ... See more keywords
Concentrating on intrinsic disorder
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Molecular Cell Biology"
DOI: 10.1038/s41580-018-0039-5
Abstract: Many eukaryotic proteins, including key transcription regulators, contain intrinsically disordered regions (IDRs), which serve as flexible interaction platforms. The molecular understanding of IDR-based interactions is now emerging, providing new insights into how IDRs promote protein… read more here.
Keywords: intrinsic disorder; biology; concentrating intrinsic;
Intrinsic disorder in the regulatory N-terminal domain of diacylglycerol acyltransferase 1 from Brassica napus
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-34339-1
Abstract: Proteins with multifunctional regulatory domains often demonstrate structural plasticity or protein disorder, allowing the binding of multiple regulatory factors and post-translational modifications. While the importance of protein disorder is clear, it also poses a challenge… read more here.
Keywords: terminal domain; intrinsic disorder; diacylglycerol acyltransferase; brassica napus ... See more keywords
Protein intrinsic disorder negatively associates with gene age in different eukaryotic lineages.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular bioSystems"
DOI: 10.1039/c7mb00230k
Abstract: The emergence of new protein-coding genes in a specific lineage or species provides raw materials for evolutionary adaptations. Until recently, the biology of new genes emerging particularly from non-genic sequences remained unexplored. Although the new… read more here.
Keywords: intrinsic disorder; young proteins; disorder; new genes ... See more keywords