Oncogenic mutations on Rac1 affect global intrinsic dynamics underlying GTP and PAK1 binding.
Sign Up to like & getrecommendations! Published in 2021 at "Biophysical journal"
DOI: 10.1016/j.bpj.2021.01.016
Abstract: Rac1 is a small member of Rho GTPase family. One of the most important downstream effectors of Rac1 is a serine/threonine kinase, p21-activated kinase 1 (PAK1). Mutational activation of PAK1 by Rac1 has oncogenic signaling… read more here.
Keywords: rac1 pak1; pak1; gtp; intrinsic dynamics ... See more keywords
A nexus of intrinsic dynamics underlies translocase priming.
Sign Up to like & getrecommendations! Published in 2021 at "Structure"
DOI: 10.1016/j.str.2021.03.015
Abstract: The cytoplasmic ATPase SecA and the membrane-embedded SecYEG channel assemble to form the Sec translocase. How this interaction primes and catalytically activates the translocase remains unclear. We show that priming exploits a nexus of intrinsic… read more here.
Keywords: underlies translocase; nexus intrinsic; translocase priming; intrinsic dynamics ... See more keywords
Intrinsic dynamics study identifies two amino acids of TIMP-1 critical for its LRP-1-mediated endocytosis in neurons
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-05039-z
Abstract: The tissue inhibitor of metalloproteinases-1 (TIMP-1) exerts inhibitory activity against matrix metalloproteinases and cytokine-like effects. We previously showed that TIMP-1 reduces neurite outgrowth in mouse cortical neurons and that this cytokine-like effect depends on TIMP-1… read more here.
Keywords: study identifies; lrp; dynamics study; identifies two ... See more keywords
Deciphering the intrinsic dynamics from the beam-induced atomic motions in oxide glasses
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Synchrotron Radiation"
DOI: 10.1107/s1600577520009753
Abstract: Analysis of the X-ray beam-induced dynamics in oxide glasses probed by X-ray photon correlation spectroscopy is presented. The results offer the possibility to estimate true sample relaxation time by performing two measurements with different X-ray… read more here.
Keywords: dynamics beam; beam induced; intrinsic dynamics; oxide glasses ... See more keywords
Can We Exploit β-Lactamases Intrinsic Dynamics for Designing More Effective Inhibitors?
Sign Up to like & getrecommendations! Published in 2020 at "Antibiotics"
DOI: 10.3390/antibiotics9110833
Abstract: β-lactamases (BLs) represent the most frequent cause of antimicrobial resistance in Gram-negative bacteria. Despite the continuous efforts in the development of BL inhibitors (BLIs), new BLs able to hydrolyze the last developed antibiotics rapidly emerge.… read more here.
Keywords: effective inhibitors; designing effective; exploit lactamases; lactamases intrinsic ... See more keywords