Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists
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DOI: 10.1126/scisignal.aaz3140
Abstract: Low intrinsic efficacy can explain the reduced side effects of apparently biased μ-opioid receptor agonists. Opioids: Efficacy versus bias Because of its antinociceptive effects, the μ-opioid receptor (MOR) is an important target for pain management,… read more here.
Keywords: low intrinsic; mor; intrinsic efficacy; efficacy ... See more keywords