Chronic Alcohol, Intrinsic Excitability, and Potassium Channels: Neuroadaptations and Drinking Behavior.
Sign Up to like & getrecommendations! Published in 2018 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2017_90
Abstract: Neural mechanisms underlying alcohol use disorder remain elusive, and this lack of understanding has slowed the development of efficacious treatment strategies for reducing relapse rates and prolonging abstinence. While synaptic adaptations produced by chronic alcohol… read more here.
Keywords: potassium channels; hyperpolarization; intrinsic excitability; chronic alcohol ... See more keywords
REST-Dependent Presynaptic Homeostasis Induced by Chronic Neuronal Hyperactivity
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurobiology"
DOI: 10.1007/s12035-017-0698-9
Abstract: Homeostatic plasticity is a regulatory feedback response in which either synaptic strength or intrinsic excitability can be adjusted up or down to offset sustained changes in neuronal activity. Although a growing number of evidences constantly… read more here.
Keywords: homeostasis; rest dependent; hyperactivity; intrinsic excitability ... See more keywords
Heterogeneities in intrinsic excitability and frequency-dependent response properties of granule cells across the blades of the rat dentate gyrus
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neurophysiology"
DOI: 10.1152/jn.00443.2019
Abstract: The dentate gyrus (DG), the input gate to the hippocampus proper, is anatomically segregated into three different sectors, namely, the suprapyramidal blade, the crest region, and the infrapyramidal blade. Although there are well-established differences between… read more here.
Keywords: dentate gyrus; intrinsic excitability; dependent response; frequency dependent ... See more keywords
Conventional measures of intrinsic excitability are poor estimators of neuronal activity under realistic synaptic inputs
Sign Up to like & getrecommendations! Published in 2021 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1009378
Abstract: Activity-dependent regulation of intrinsic excitability has been shown to greatly contribute to the overall plasticity of neuronal circuits. Such neuroadaptations are commonly investigated in patch clamp experiments using current step stimulation and the resulting input-output… read more here.
Keywords: activity; firing responses; synaptic inputs; intrinsic excitability ... See more keywords
Adaptation and Inhibition Control Pathological Synchronization in a Model of Focal Epileptic Seizure
Sign Up to like & getrecommendations! Published in 2018 at "eNeuro"
DOI: 10.1523/eneuro.0019-18.2018
Abstract: Visual Abstract Pharmacoresistant epilepsy is a common neurological disorder in which increased neuronal intrinsic excitability and synaptic excitation lead to pathologically synchronous behavior in the brain. In the majority of experimental and theoretical epilepsy models,… read more here.
Keywords: adaptation inhibition; inhibition; intrinsic excitability; model ... See more keywords
Subregional Differences in Medium Spiny Neuron Intrinsic Excitability Properties between Nucleus Accumbens Core and Shell in Male Rats
Sign Up to like & getrecommendations! Published in 2023 at "eNeuro"
DOI: 10.1523/eneuro.0432-22.2023
Abstract: Abstract The nucleus accumbens (NAc) is known for its central role in reward and motivation (Day and Carelli, 2007; Floresco, 2015; Salgado and Kaplitt, 2015). Decades of research on the cellular arrangement, density, and connectivity… read more here.
Keywords: core shell; nucleus accumbens; intrinsic excitability; shell ... See more keywords
The Alteration of Intrinsic Excitability and Synaptic Transmission in Lumbar Spinal Motor Neurons and Interneurons of Severe Spinal Muscular Atrophy Mice
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2019.00015
Abstract: Spinal muscular atrophy (SMA) is the leading genetic cause of death in infants. Studies with mouse models have demonstrated increased excitability and loss of afferent proprioceptive synapses on motor neurons (MNs). To further understand functional… read more here.
Keywords: sma mice; intrinsic excitability; mns; motor ... See more keywords
Altered membrane properties but unchanged intrinsic excitability and spontaneous postsynaptic currents in an aged APPswe/PS1dE9 model of Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.958876
Abstract: Neuronal hyperexcitability in Alzheimer’s disease (AD) models is thought to either contribute to the formation of amyloid beta plaques or result from their formation. Neuronal hyperexcitability has been shown in the cerebral cortex of the… read more here.
Keywords: alzheimer disease; appswe ps1de9; excitability spontaneous; spontaneous postsynaptic ... See more keywords
Kv1.1 contributes to a rapid homeostatic plasticity of intrinsic excitability in CA1 pyramidal neurons in vivo
Sign Up to like & getrecommendations! Published in 2019 at "eLife"
DOI: 10.7554/elife.49915
Abstract: In area CA1 of the hippocampus, the selection of place cells to represent a new environment is biased towards neurons with higher excitability. However, different environments are represented by orthogonal cell ensembles, suggesting that regulatory… read more here.
Keywords: excitability; ca1 pyramidal; intrinsic excitability; pyramidal neurons ... See more keywords