Contact and intrinsic coagulation pathways are activated and associated with adverse clinical outcomes in COVID-19
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DOI: 10.1182/bloodadvances.2021006620
Abstract: Coagulation activation is a prominent feature ofSARS-CoV-2infection (COVID-19). Activation of the contact system and intrinsic pathway has increasingly been implicated in the prothrombotic state observed in both sterile and infectious inflammatory conditions. We thus sought… read more here.
Keywords: intrinsic pathway; contact intrinsic; adverse clinical; activation ... See more keywords
Protopine triggers apoptosis via the intrinsic pathway and regulation of ROS/PI3K/Akt signalling pathway in liver carcinoma
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DOI: 10.1186/s12935-021-02105-5
Abstract: Background Protopine is an isoquinoline alkaloid that possesses various biological activities including the anti-tumour activity. However, the effects of protopine on liver carcinoma cells are still elusive. The aim of this study is to examine… read more here.
Keywords: protopine; pi3k akt; liver carcinoma; via intrinsic ... See more keywords
Activating the Intrinsic Pathway of Apoptosis Using BIM BH3 Peptides Delivered by Peptide Amphiphiles with Endosomal Release
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DOI: 10.3390/ma12162567
Abstract: Therapeutic manipulation of the BCL-2 family using BH3 mimetics is an emerging paradigm in cancer treatment and immune modulation. For example, peptides mimicking the BIM BH3 helix can directly target the full complement of anti-… read more here.
Keywords: activating intrinsic; apoptosis; bh3; bim bh3 ... See more keywords