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Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.04.034
Abstract: Intrinsic resistance in Pseudomonas aeruginosa, defined by chromosomally encoded low outer membrane permeability and constitutively over-expressed efflux pumps, is a major reason why the pathogen is refractory to many antibiotics. Herein, we report that heterodimeric…
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Keywords:
intrinsic resistance;
rifampicin tobramycin;
resistance pseudomonas;
pseudomonas aeruginosa ... See more keywords
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Published in 2022 at "Nature Chemical Biology"
DOI: 10.1038/s41589-022-00980-1
Abstract: Precision oncology requires an understanding of the genes and pathways that dictate therapeutic response. Through specialized analysis of drug sensitivity patterns across hundreds of genomically annotated cancer cell lines, specific and actionable drivers of intrinsic…
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Keywords:
oncology;
biology;
drivers intrinsic;
intrinsic resistance ... See more keywords
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Published in 2023 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00686-22
Abstract: Procedures such as solid-organ transplants and cancer treatments can leave many patients in an immunocompromised state. This leads to their increased susceptibility to opportunistic diseases such as fungal infections. ABSTRACT Procedures such as solid-organ transplants…
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Keywords:
fksa fksb;
mucor circinelloides;
calcineurin;
intrinsic resistance ... See more keywords
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Published in 2023 at "Journal of Clinical Microbiology"
DOI: 10.1128/jcm.01326-22
Abstract: A bacterial species is considered to be intrinsically resistant to an antimicrobial when nearly all of the wild-type isolates (i.e., those without acquired resistance) exhibit minimum inhibitory concentration (MIC) values that are sufficiently high such…
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Keywords:
hafnia;
intrinsic resistance;
susceptibility testing;
colistin ... See more keywords
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Published in 2019 at "mBio"
DOI: 10.1128/mbio.00189-19
Abstract: Resistance to antibiotics often evolves when bacteria encounter antibiotics. However, bacterial strains and species without any known exposure to these drugs also vary in their intrinsic susceptibility. In many cases, evolved resistance has been shown…
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Keywords:
susceptible antibiotics;
susceptibility;
resistance;
000 generations ... See more keywords
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Published in 2022 at "mBio"
DOI: 10.1128/mbio.00425-22
Abstract: A widely investigated mode of antibiotic resistance occurs via mutations and/or by horizontal acquisition of resistance genes. In addition to this acquired resistance, most bacteria exhibit intrinsic resistance as an inducible and adaptive response to…
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Keywords:
antibiotic resistance;
bactericidal antibiotics;
iron;
intrinsic resistance ... See more keywords
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Published in 2020 at "Journal of thoracic disease"
DOI: 10.21037/jtd.2019.12.97
Abstract: Background About 20-30% EGFR-mutant non-small lung cancer show intrinsic resistance to EGFR targeted therapies. Compared to T790M positive in acquired resistance patients, little is known about EGFR-TKI intrinsic resistance for T790M negative patients. Methods Thirty-one…
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Keywords:
egfr targeted;
free dna;
cell free;
intrinsic resistance ... See more keywords
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Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.758571
Abstract: Polymyxin is the “last resort” of antibiotics. The self-induced resistance to polymyxin in Gram-negative bacteria could be mediated by lipopolysaccharide (LPS) modification, which is regulated by the two-component system, PhoP/PhoQ. Yersinia enterocolitica is a common…
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Keywords:
enterocolitica;
phop phoq;
intrinsic resistance;
phoq ... See more keywords