Heterodimeric Rifampicin-Tobramycin conjugates break intrinsic resistance of Pseudomonas aeruginosa to doxycycline and chloramphenicol in vitro and in a Galleria mellonella in vivo model.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.04.034
Abstract: Intrinsic resistance in Pseudomonas aeruginosa, defined by chromosomally encoded low outer membrane permeability and constitutively over-expressed efflux pumps, is a major reason why the pathogen is refractory to many antibiotics. Herein, we report that heterodimeric… read more here.
Keywords: intrinsic resistance; rifampicin tobramycin; resistance pseudomonas; pseudomonas aeruginosa ... See more keywords
Drivers of intrinsic resistance
Sign Up to like & getrecommendations! Published in 2022 at "Nature Chemical Biology"
DOI: 10.1038/s41589-022-00980-1
Abstract: Precision oncology requires an understanding of the genes and pathways that dictate therapeutic response. Through specialized analysis of drug sensitivity patterns across hundreds of genomically annotated cancer cell lines, specific and actionable drivers of intrinsic… read more here.
Keywords: oncology; biology; drivers intrinsic; intrinsic resistance ... See more keywords
Serine/Threonine Phosphatase Calcineurin Orchestrates the Intrinsic Resistance to Micafungin in the Human-Pathogenic Fungus Mucor circinelloides
Sign Up to like & getrecommendations! Published in 2023 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.00686-22
Abstract: Procedures such as solid-organ transplants and cancer treatments can leave many patients in an immunocompromised state. This leads to their increased susceptibility to opportunistic diseases such as fungal infections. ABSTRACT Procedures such as solid-organ transplants… read more here.
Keywords: fksa fksb; mucor circinelloides; calcineurin; intrinsic resistance ... See more keywords
Intrinsic Resistance to Colistin in the Genus Hafnia
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Clinical Microbiology"
DOI: 10.1128/jcm.01326-22
Abstract: A bacterial species is considered to be intrinsically resistant to an antimicrobial when nearly all of the wild-type isolates (i.e., those without acquired resistance) exhibit minimum inhibitory concentration (MIC) values that are sufficiently high such… read more here.
Keywords: hafnia; intrinsic resistance; susceptibility testing; colistin ... See more keywords
Changes in Intrinsic Antibiotic Susceptibility during a Long-Term Evolution Experiment with Escherichia coli
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DOI: 10.1128/mbio.00189-19
Abstract: Resistance to antibiotics often evolves when bacteria encounter antibiotics. However, bacterial strains and species without any known exposure to these drugs also vary in their intrinsic susceptibility. In many cases, evolved resistance has been shown… read more here.
Keywords: susceptible antibiotics; susceptibility; resistance; 000 generations ... See more keywords
Iron-Induced Respiration Promotes Antibiotic Resistance in Actinomycete Bacteria
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DOI: 10.1128/mbio.00425-22
Abstract: A widely investigated mode of antibiotic resistance occurs via mutations and/or by horizontal acquisition of resistance genes. In addition to this acquired resistance, most bacteria exhibit intrinsic resistance as an inducible and adaptive response to… read more here.
Keywords: antibiotic resistance; bactericidal antibiotics; iron; intrinsic resistance ... See more keywords
Identification of somatic copy number variations in plasma cell free DNA correlating with intrinsic resistances to EGFR targeted therapy in T790M negative non-small cell lung cancer.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of thoracic disease"
DOI: 10.21037/jtd.2019.12.97
Abstract: Background About 20-30% EGFR-mutant non-small lung cancer show intrinsic resistance to EGFR targeted therapies. Compared to T790M positive in acquired resistance patients, little is known about EGFR-TKI intrinsic resistance for T790M negative patients. Methods Thirty-one… read more here.
Keywords: egfr targeted; free dna; cell free; intrinsic resistance ... See more keywords
The Role of the Two-Component System PhoP/PhoQ in Intrinsic Resistance of Yersinia enterocolitica to Polymyxin
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.758571
Abstract: Polymyxin is the “last resort” of antibiotics. The self-induced resistance to polymyxin in Gram-negative bacteria could be mediated by lipopolysaccharide (LPS) modification, which is regulated by the two-component system, PhoP/PhoQ. Yersinia enterocolitica is a common… read more here.
Keywords: enterocolitica; phop phoq; intrinsic resistance; phoq ... See more keywords