Roles of minor spliceosome in intron recognition and the convergence with the better understood major spliceosome
Sign Up to like & getrecommendations! Published in 2022 at "Wiley Interdisciplinary Reviews: RNA"
DOI: 10.1002/wrna.1761
Abstract: Catalyzed by spliceosomes in the nucleus, RNA splicing removes intronic sequences from precursor RNAs in eukaryotes to generate mature RNA, which also significantly increases proteome complexity and fine‐tunes gene expression. Most metazoans have two coexisting… read more here.
Keywords: recognition; intron; minor spliceosome; spliceosome ... See more keywords
Knocking down Israa, the Zmiz1 intron-nested gene, unveils interrelated T cell activation functions in mouse
Sign Up to like & getrecommendations! Published in 2021 at "Biochemistry and Biophysics Reports"
DOI: 10.1016/j.bbrep.2021.101100
Abstract: We previously reported Israa (immune-system-released activating agent), a novel gene nested in intron 6 of the mouse Zmiz1 gene. Zmiz1 is involved in several functions such as fertility and T cell development and its knockout… read more here.
Keywords: gene; cell activation; israa; intron ... See more keywords
Intron-retained transcripts of the spinal muscular atrophy genes, SMN1 and SMN2
Sign Up to like & getrecommendations! Published in 2018 at "Brain and Development"
DOI: 10.1016/j.braindev.2018.03.001
Abstract: BACKGROUND The SMN genes, SMN1 and SMN2, are highly homologous genes which are related to the development or clinical severity of spinal muscular atrophy. Some alternative splicing patterns of the SMN genes have been well… read more here.
Keywords: genes smn1; intron; retained transcripts; retained smn ... See more keywords
Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12 Intron Splicing-Defective Zrsr1 Mutant Mice.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.03.028
Abstract: The U2AF35-like ZRSR1 has been implicated in the recognition of 3' splice site during spliceosome assembly, but ZRSR1 knockout mice do not show abnormal phenotypes. To analyze ZRSR1 function and its precise role in RNA splicing, we… read more here.
Keywords: zrsr1 mutant; intron; mutant mice; mice ... See more keywords
Regulation of alternative splicing of PaFT and PaFDL1, the FT and FD homologs in Platanus acerifolia.
Sign Up to like & getrecommendations! Published in 2022 at "Gene"
DOI: 10.1016/j.gene.2022.146506
Abstract: Alternative splicing (AS) selects different alternative splice sites and produces a variety of transcripts with different exon/intron combinations, which may result in multiple protein isoforms. The splicing signals include cis-elements and RNA structures; however, the… read more here.
Keywords: alternative splicing; splice; alternative splice; intron ... See more keywords
Interplay of ERα binding and DNA methylation in the intron-2 determines the expression and estrogen regulation of cystatin A in breast cancer cells
Sign Up to like & getrecommendations! Published in 2020 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2020.110701
Abstract: Despite advances in early detection and treatment, invasion and metastasis of breast tumors remains a major hurdle. Cystatin A (CSTA, also called stefin A), an estrogen-regulated gene in breast cancer cells, is an inhibitor of… read more here.
Keywords: breast; intron; estrogen; expression ... See more keywords
Intron-specific patterns of divergence of lin-11 regulatory function in the C. elegans nervous system.
Sign Up to like & getrecommendations! Published in 2017 at "Developmental biology"
DOI: 10.1016/j.ydbio.2017.02.005
Abstract: The diversity of neurons in the nervous system is specified by many genes, including those that encode transcription factors (TFs) and play crucial roles in coordinating gene transcription. To understand how the spatiotemporal expression of… read more here.
Keywords: lin; intron; nervous system; expression ... See more keywords
Monitoring the promoter activity of long noncoding RNAs and stem cell differentiation through knock-in of sgRNA flanked by tRNA in an intron
Sign Up to like & getrecommendations! Published in 2021 at "Cell Discovery"
DOI: 10.1038/s41421-021-00272-3
Abstract: Dear Editor, The majority of mammalian genome is transcribed to RNA transcripts, of which only a very small percentage code for proteins. As a result, thousands of RNAs that do not code for proteins are… read more here.
Keywords: intron; lncenc1; expression; differentiation ... See more keywords
A spliceosomal twin intron (stwintron) participates in both exon skipping and evolutionary exon loss
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-46435-x
Abstract: Spliceosomal twin introns (stwintrons) are introns where any of the three consensus sequences involved in splicing is interrupted by another intron (internal intron). In Aspergillus nidulans, a donor-disrupted stwintron (intron-1) is extant in the transcript… read more here.
Keywords: twin intron; spliceosomal twin; intron; intervening sequence ... See more keywords
Pentatricopeptide repeat protein MID1 modulates nad2 intron 1 splicing and Arabidopsis development
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-58495-5
Abstract: As one of the best-studied RNA binding proteins in plant, pentatricopeptide repeats (PPRs) protein are mainly targeted to mitochondria and/or chloroplasts for RNA processing to regulate the biogenesis and function of the organelles, but its… read more here.
Keywords: nad2 intron; protein; intron splicing; intron ... See more keywords
Transposable elements drive intron gain in diverse eukaryotes
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2209766119
Abstract: There is massive variation in intron numbers across eukaryotic genomes, yet the major drivers of intron content during evolution remain elusive. Rapid intron loss and gain in some lineages contrasts with long term evolutionary stasis… read more here.
Keywords: intron; elements drive; transposable elements; gain ... See more keywords