Timely-regulated intron retention as device to fine-tune protein expression
Sign Up to like & getrecommendations! Published in 2017 at "Cell Cycle"
DOI: 10.1080/15384101.2017.1337983
Abstract: A key step in pre-mRNA processing is represented by splicing, the multilayered process operated by the spliceosome that removes the intervening non-coding introns and ligates adjacent exons. Splicing is necessary to yield a mature, translatable… read more here.
Keywords: intron; gene expression; intron retaining; intron retention ... See more keywords
Physiological intron retaining transcripts in the cytoplasm abound during human motor neurogenesis
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DOI: 10.1101/gr.276898.122
Abstract: Intron retention (IR) is now recognized as a dominant splicing event during motor neuron (MN) development; however, the role and regulation of intron-retaining transcripts (IRTs) localized to the cytoplasm remain particularly understudied. Here we show… read more here.
Keywords: intron; transcripts cytoplasm; intron retaining; physiological intron ... See more keywords
Intron retention enhances gene regulatory complexity in vertebrates
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DOI: 10.1186/s13059-017-1339-3
Abstract: BackgroundWhile intron retention (IR) is now widely accepted as an important mechanism of mammalian gene expression control, it remains the least studied form of alternative splicing. To delineate conserved features of IR, we performed an… read more here.
Keywords: regulatory complexity; gene regulatory; intron retaining; intron retention ... See more keywords