Bioinformatics detection of modulators controlling splicing factor‐dependent intron retention in the human brain
Sign Up to like & getrecommendations! Published in 2022 at "Human Mutation"
DOI: 10.1002/humu.24379
Abstract: Alternative RNA splicing is an important means of genetic control and transcriptome diversity. However, when alternative splicing events are studied independently, coordinated splicing modulated by common factors is often not recognized. As a result, the… read more here.
Keywords: detection modulators; intron retention; splicing factor; bioinformatics detection ... See more keywords
Intron retention and its impact on gene expression and protein diversity: A review and a practical guide
Sign Up to like & getrecommendations! Published in 2020 at "Wiley Interdisciplinary Reviews: RNA"
DOI: 10.1002/wrna.1631
Abstract: Intron retention (IR) occurs when a complete and unspliced intron remains in mature mRNA. An increasing body of literature has demonstrated a major role for IR in numerous biological functions, including several that impact human… read more here.
Keywords: gene expression; impact gene; intron retention; expression protein ... See more keywords
A dynamic intron retention program regulates the expression of several hundred genes during pollen meiosis.
Sign Up to like & getrecommendations! Published in 2021 at "Plant reproduction"
DOI: 10.1007/s00497-021-00411-6
Abstract: KEY MESSAGE Intron retention is a stage-specific mechanism of functional attenuation of a subset of co-regulated, functionally related genes during early stages of pollen development. To improve our understanding of the gene regulatory mechanisms that… read more here.
Keywords: stage specific; retention; several hundred; intron retention ... See more keywords
Intron retention as an alternative splice variant of the cattle ANGPTL6 gene.
Sign Up to like & getrecommendations! Published in 2019 at "Gene"
DOI: 10.1016/j.gene.2019.05.031
Abstract: Angiopoietin-like protein 6, which is encoded by ANGPTL6 gene (also known as angiopoietin growth factor, AGF), has been extensively characterized with regard to its proposed functions as angiogenesis and energy metabolism. The present results showed… read more here.
Keywords: splice variant; gene; intron retention; angptl6 gene ... See more keywords
Nanopore sequencing of brain-derived full-length circRNAs reveals circRNA-specific exon usage, intron retention and microexons
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-24975-z
Abstract: Circular RNA (circRNA) is a class of covalently joined non-coding RNAs with functional roles in a wide variety of cellular processes. Their composition shows extensive overlap with exons found in linear mRNAs making it difficult… read more here.
Keywords: retention microexons; intron retention; nanopore sequencing; brain ... See more keywords
Post-transcriptional splicing of nascent RNA contributes to widespread intron retention in plants
Sign Up to like & getrecommendations! Published in 2020 at "Nature Plants"
DOI: 10.1038/s41477-020-0688-1
Abstract: In eukaryotes, genes are transcribed by RNA polymerase-II (Pol-II) and introns are removed by the spliceosome largely cotranscriptionally 1 – 3 ; analysis using long-read sequencing revealed that splicing occurs immediately after Pol-II passes introns… read more here.
Keywords: intron retention; transcriptional splicing; post transcriptional; rna ... See more keywords
Timely-regulated intron retention as device to fine-tune protein expression
Sign Up to like & getrecommendations! Published in 2017 at "Cell Cycle"
DOI: 10.1080/15384101.2017.1337983
Abstract: A key step in pre-mRNA processing is represented by splicing, the multilayered process operated by the spliceosome that removes the intervening non-coding introns and ligates adjacent exons. Splicing is necessary to yield a mature, translatable… read more here.
Keywords: intron; gene expression; intron retaining; intron retention ... See more keywords
Increased chromatin accessibility facilitates intron retention in specific cell differentiation states
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac994
Abstract: Abstract Dynamic intron retention (IR) in vertebrate cells is of widespread biological importance. Aberrant IR is associated with numerous human diseases including several cancers. Despite consistent reports demonstrating that intrinsic sequence features can help introns… read more here.
Keywords: chromatin accessibility; cell; increased chromatin; intron retention ... See more keywords
Increased intron retention is a post‐transcriptional signature associated with progressive aging and Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2019 at "Aging Cell"
DOI: 10.1111/acel.12928
Abstract: Intron retention (IR) by alternative splicing is a conserved regulatory mechanism that can affect gene expression and protein function during adult development and age‐onset diseases. However, it remains unclear whether IR undergoes spatial or temporal… read more here.
Keywords: alzheimer disease; intron retention; signature associated;
Splicing Control in Normal and Aberrant Erythropoiesis
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-109414
Abstract: Alternative splicing is employed by all eukaryotic cells to increase proteome diversity and to regulate gene expression. RNA sequencing analysis of purified populations of erythroblasts at different stages of maturation has led to the identification… read more here.
Keywords: splice; point mutations; mrna splicing; intron retention ... See more keywords
Intron retention enhances gene regulatory complexity in vertebrates
Sign Up to like & getrecommendations! Published in 2017 at "Genome Biology"
DOI: 10.1186/s13059-017-1339-3
Abstract: BackgroundWhile intron retention (IR) is now widely accepted as an important mechanism of mammalian gene expression control, it remains the least studied form of alternative splicing. To delineate conserved features of IR, we performed an… read more here.
Keywords: regulatory complexity; gene regulatory; intron retaining; intron retention ... See more keywords